gonadal dysgenesis

(redirected from Streak gonad)
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gonadal dysgenesis

[gō′nad·əl dis′jen·ə·səs]
(medicine)
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AGD refers to individuals who usually have a differentiated gonad on one side and a streak gonad or streak testis on other side.
1] Most patients have a 45,X/46,XY karyotype, and have an abnormal testis with contralateral streak gonad.
Dysgenesis of testicular and streak gonads in the syndrome of mized gonadal dysgenesis: Perspective Derived from a Clinicopathologic Analysis of Twenty-one Cases.
However, gonadal development may range from apparently normal testicular differentiation to a streak gonad, and the criteria for the histologic diagnosis of DMP are not well established.
In fact, some authors consider DMP a variant of mixed gonadal dysgenesis,[4,8-9] which is defined as the coexistence of a streak gonad and a dysgenetic testis in a patient with a 45,X/46,XY karyotype.
Although X-autosome translocations are frequently associated with streak gonads and clinical features of the Turner syndrome, the majority of X-autosome carriers may present with a variable phenotype, developmental delay, and recognizable X-linked syndrome due to nonrandom X-inactivation.
The problem manifests itself at puberty as a result of an inability of the streak gonads to produce sex hormones (both oestrogens and androgens).
One case of primary amenorrhea studied laparoscopic ally shows bilateral streak gonads with absent of uterus.
This case series describes the clinical features of patients presented with primary amenorrhoea and streak gonads from a single village and their response to treatment in a tertiary care hospital, and also to trace the source of genetic insult.
On ultrasound examination-rudimentary, streak gonads adjacent to bladder were detected on the left side (Figure 6).