astrocytoma

(redirected from Subependymal Giant Cell Astrocytoma)
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Related to Subependymal Giant Cell Astrocytoma: subependymoma

astrocytoma

[‚as·trə‚sī′tōm·ə]
(medicine)
A slow-growing glial tumor made up of cells resembling astrocytes; often it will undergo malignant change and assume the appearance and growth characteristics of a glioblastoma.
References in periodicals archive ?
Tumors related to tuberous sclerosis were renal angiomyolipomas in 21 patients, cardiac rhabdomyomas in 11, subependymal giant cell astrocytomas in seven, and non renal hamartoma in one patient.
Subependymal giant cell astrocytomas are histologically benign tumors located near the foramen of Monro.
The patient presented with a new onset seizure and was found to have multiple cortical tubers and subependymal giant cell astrocytoma on brain imaging.
Food and Drug Administration (FDA) for two clinical manifestations of TSC disease: treatment of subependymal giant cell astrocytomas (SEGAs), non-cancerous brain tumors, and renal angiomyolipomas (AMLs), noncancerous kidney tumors.
Mammalian target of rapamycin inhibitors for intractable epilepsy and subependymal giant cell astrocytomas in tuberous sclerosis complex.
Histologically, they consist of bland spindle-shaped and polygonal fibrous astrocytes, or large cells with glassy, eosinophilic cytoplasm, similar to gemistocytes of subependymal giant cell astrocytoma.
It also marks the second TSC-related indication for Afinitor in the US, where it is also approved to treat subependymal giant cell astrocytoma (SEGA) in TSC.
8 September 2011 - Swiss drug maker Novartis AG (VTX: NOVN) announced today it has received an approval from the European Commission (EC) for Votubia tablets (everolimus) for the treatment of patients with subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (TSC), who require therapeutic intervention but are not amenable to surgery.
Diagnostic Criteria for Tuberous Sclerosis Complex * Major features * Facial angiofibromas or forehead plaque * Nontraumatic ungual or periungual fibroma * Hvpomelanotic macules (more than three) * Shagreen patch (connective tissue nevus) * Cortical tuber * Subependymal nodule * Subependymal giant cell astrocytoma * Multiple retinal nodular hamartomas * Cardiac rhabdomyoma, single or multiple * Lymphangiomyomatosis * Renal angiomyolipoma * Minor features * Multiple randomly distributed pits in dental enamel * Hamartomatous rectal polyps * Bone cysts * Cerebral white matter "migration tracts"" * Gingival fibromas * Nonrenal hamartoma * Retinal achromic patch * "Confetti" skin lesions * Multiple renal cysts