Inside the intact cells of an onion, a molecule called sulfenic acid
precursor floats around the watery filler like a napping human in a lazy river.
2] thiol groups on cysteine residues to produce sulfenic acid
Garlic contains the compound allicin, which releases the powerful antioxidant sulfenic acid
as it is broken down by the body.
The new method detects sulfenic acid in proteins-a tip off to early oxidative stress and to a specific protein modification associated with cell growth pathways.
Sulfenic acid is produced when a particular oxidant, hydrogen peroxide, reacts with the protein building block cysteine.
During the decomposition of allicin, sulfenic acid
is formed, which acts as a free radical scavenger.
Monosulfidic crosslinks are expected to decompose into sulfenic acid
derivatives, which are postulated as powerful antioxidants (ref.
Susceptible cysteine residues in redoxsensitive proteins exist as a thiolate anion in a physiological pH and they can be reversibly oxidized by hydrogen peroxide to yield sulfenic acid (SO-).
2] and promote the inactivation of protein tyrosine phosphatase 1B (PTP1B) by oxidizing the catalytic cysteine residues into sulfenic acid .
The reaction between the sulfenic acid
and radicals is as fast as it can get, limited only by the time it takes for the two molecules to come into contact.
Their topics include the fabulous destiny of sulfenic acids
, sustainable catalytic oxidations with peroxides, the iridium-catalyzed hydrogenation of minimally functionalized olefins using phosphite-nitrogen ligands, golden times for allenes, and the synthesis of chiral imidate ligands and their applications in asymmetric catalysis.
This reacts with the onion to produce sulfenic acids
, which immediately turn into synpropanethial- S-oxide.