Sulfone

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sulfone

[′səl‚fōn]
(organic chemistry)
R2SO2(or RSOOR) A compound formed by the oxidation of sulfides, for example, ethyl sulfone, C4H10SO2, from ethyl sulfide, C4H10S; the use of sulfones, particularly 4,4′-sulfonyldianiline (dapsone) in the treatment of leprosy leads to apparent improvement; relapses associated with sulfone-resistant strains have been encountered.

Sulfone

 

any of several organosulfur compounds containing the

group bonded to two organic radicals. Sulfones are colorless and very stable crystalline substances; for example, diphenylsulfone, (C6H5)2SO2, melts at 128°C and boils at 379°C. Both aliphatic and aromatic sulfones are obtained by oxidation of organic sulfides; aromatic sulfones are also obtained by means of the Friedel-Crafts reaction.

Some substituted sulfones are used in medicine—for example, diaphenylsulfone (4,4’-diaminodiphenylsulfone) is used in the treatment of leprosy. Polyarylenesulfones are used for the production of packages for foodstuffs and electrotechnical parts.

References in periodicals archive ?
Phenyl vinyl sulfone was removed by triturating with a small amount of proapan-2-ol was performed to give the title compound.
Dapsone (4, 4'-diamino-diphenyl sulfone, DDS) is a sulphone drug.
Over time, different terminologies have been used for DHS; Lowe and Allday first described it in 1950 under the name of DDS syndrome or sulfone syndrome.
This strategic joint venture will enable us to maintain our market growth and meet increasing customer demands for sulfone monomers and derivatives alongside other key products," said Rich Preziotti, President and Chief Executive Officer of Vertellus Specialties.
Several sulfones have been known as inhibitors of erythocytic malaria parasites on cysteine and aspartic proteases (Rosenthal et al.
Using the oxidation process it is possible to convert thiophene, benzothiophene, dibenzothiophene and their methyl and higher alkyl derivatives into sulfones and sulfoxides.
Instituto Mexicano del Petroleo (Mexico) and Universidad Nacional Autonoma de Mexico (Mexico) have patented a method of removing thiophenic and organosulfide compounds from a fossil fuel comprising the steps of contacting the fossil fuel with hemoproteins, which oxidize the sulfur containing compounds to sulfoxides and sulfones in a reaction system containing organic solvent or not, and followed by a distillation step in which sulfoxides and sulfones are removed from the fuel.
Covering first synthetic methods then synthetic intermediates, they consider such topics as the metal-free oxidative lactonization of carbohydrates using molecular iodine, the synthesis of glycosyl vinyl sulfones for bioconjugation, and lactose-modified triethoxysilane for modifying the surface of clay nanocomposites.
There are several methods of synthesizing DCDPS but many of them give low yields, DCDPS was used as starting material in the proposed route for synthesis of polysulfones, polyether sulfones, and polyphenyl sulfones.
Chiral PCB methyl sulfones in rat tissues after exposure to technical PCBs.
In the past, this seemed to be a domain for specialists; today every synthetic chemist working in these areas are expected to synthesize compounds containing sulfides, sulfates, sulfones, etc.