symporter


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symporter

[sim′pȯrd·ər]
(cell and molecular biology)
A channel protein that simultaneously transports two different types of substrates (for example, sodium ion plus glucose) across a cell membrane, both in the same direction.
References in periodicals archive ?
22) Uptake of inorganic iodide by the thyroidal Na/I symporter system increases with increased peripheral levels, but only up to a point.
The sodium iodide symporter that is expressed in the thyroid gland is also expressed in lactating mammary gland.
BACKGROUND: Perchlorate and thiocyanate interfere with iodide uptake at the sodium-iodide symporter and are potential disruptors of thyroid hormone synthesis.
Estradiol has been shown to block TSH-induced sodium/iodide symporter (NIS) expression in the FRTL5 rat follicular cell line (Furlanetto et al.
Iodide is actively transported via a transmembrane protein known as the sodium-iodide symporter (NIS) into thyroid cells.
if inhibition of iodide uptake by the thyroid is duration-dependent, the effect should decrease rather than increase with time, because compensation would increase the activity of the sodiumiodide symporter and therefore increase iodide transport into the thyroid.
2005) suggest up-regulation of the iodide symporter in these workers, a protective mechanism that may not exist in the fetus or neonate.
Some examples of these chemicals include environmental phenols such as bisphenol-A (BPA) used as a plasticizer in the plastic industry, and sodium-iodide symporter inhibitors such as nitrates used in the fertiliser industry.
Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS).
The aim of this study is to investigate the presence and localization of sodium iodide symporter (NIS) expression in pure testicular seminomas, two lymph nodes with seminoma metastasis, and two embryonal carcinomas by immunohistochemically methods.
Histone deacetylase inhibition affects sodium iodide symporter expression and induces 131I cytotoxicity in anaplastic thyroid cancer cells.