symporter


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symporter

[sim′pȯrd·ər]
(cell and molecular biology)
A channel protein that simultaneously transports two different types of substrates (for example, sodium ion plus glucose) across a cell membrane, both in the same direction.
References in periodicals archive ?
In a rat thyroid cell line, DEHP and DBP appeared to affect iodide uptake activity through modulation of sodium/iodide symporter (Wenzel et al.
Investigators have developed assays for the detection of circulating mRNA species coding for thyroid peroxidase (TPO), the sodium iodine symporter (NIS), pendrin (PDS), the thyrotropin receptor (TSHR) and Tg.
Yves Ambroise and colleagues at Biology and Technology Institute at the French Alternative Energies and Atomic Energy Commission identified an important class of compounds that efficiently blocks iodide transport by inhibiting the sodium iodide symporter, and their results are reported in ChemMedChem.
As a response to an acute iodine load, the normal thyroid transiently decreases the synthesis of thyroid hormones but then recovers due to a decrease in the thyroid sodium/iodide symporter, resulting a decrease in iodine transport into the thyroid and resumption of normal thyroid hormone synthesis (7).
Both breast and thyroid tissue share the same sodium-iodide symporter, and the immune system may simply target an antigen the two have in common.
The more aggressive behavior of BRAF V600E-positive tumors may be due to the propensity of these tumors to dedifferentiate and to the fact that this mutation leads to the alteration of function of sodium iodide symporter (NIS) and other genes metabolizing iodide, thus decreasing the ability of tumors to trap radioiodine and predisposing to treatment failure of the recurrent disease.
131]I treatment takes advantage of the fact that thyroid cells have the ability to absorb iodine after oral administration due to the presence of an active sodium iodide symporter.
The dedifferentiated cells have lost the human sodium-iodide symporter function, so radioiodine therapy is not as efficacious.
These drugs have their effect on the sodium-potassium-chloride symporter (Cotransporter) in the thick ascending limb of the loop of Henle.
Iodine may also have important antioxidant functions in breast tissue and other tissues that concentrate iodine via the sodium iodide symporter.
Other evidence, adding biologic plausibility to the hypothesis that iodine prevents breast cancer, includes the finding that the ductal cells in the breast, the ones most likely to become cancerous, are equipped with an iodine pump, the sodium-iodide symporter, the same one the thyroid gland has, to absorb this element.
Altered gene expression profles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary DNA microarray.