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TATA box

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TATA box [′tä‚tä ‚bäks or ¦tē¦ā¦tē′ā ‚bäks]
(genetics)
In eukaryotes, a short sequence of base pairs that is rich in adenine (A) and thymidine (T) residues and located about 25-30 nucleotides upstream of the transcriptional initiation site.


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The sequence also has a TATA box located between 15 and 25 nucleotides in the 3' direction of the closest Dof element.
Once the transcription factors bind to the TATA box the genes start making mRNA.
[41] However, Hoechst 33342-induced apoptosis is associated with mitochondrial dysfunction,[41] inhibition of endogenous topoisomerase I activity,[25,26,40,41] and decreased formation of normal TATA box-binding protein/ TATA box complexes,[24,27] suggesting that Hoechst 33342-induced apoptosis is associated with a novel mechanism.
 
 
 
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