Telomere


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telomere

[′tel·ə‚mir]
(cell and molecular biology)
A centromere in the terminal position on a chromosome.

Telomere

 

the terminal segment of a chromosome. When chromosomes become fragmented, as through the action of ionizing radiation, some of the fragments may reunite, but they never reunite along the telomere. Consequently, telomeres prevent the joining of other segments of chromosomes.

References in periodicals archive ?
In fact, any increase in time spent exercising was associated with a nonsignificant trend toward shorter telomere length.
They found that the ATR inhibitors VE-821 and AZ20 selectively eliminated ALT-positive osteosarcoma and glioblastoma cells from panels of cancer cell lines, suppressing their ability to extend their telomeres though recombination and leading to the cells' death.
TEHRAN (FNA)- A new procedure can quickly and efficiently increase the length of human telomeres, the protective caps on the ends of chromosomes that are linked to aging and disease, according to scientists.
Participants completed detailed food questionnaires and had a blood test to measure telomere length.
16] reported that women with high-intensity training (MET<6) had longer telomere lengths than women with low- and moderate-intensity training, which may be due to estrogen effect in up regulation of telomerase [16] In the present study, increased telomerase activity due to intense exercise could explain increased telomere length.
Shorter telomeres are associated with a decreased life expectancy and increased rate of aging-related disease.
The authors calculated that the difference in telomere length among women who were more adherent to the Mediterranean diet could translate into an average gain of about 4.
Life Length, a healthcare diagnostics company founded in 2010 to offer its proprietary Telomere Analysis Technology (TAT) is the only company in the world able to measure telomeres individually at the chromosomal level, providing the crucial measure for cell senescence, aging and age-related diseases.
More recent studies found that high quality, high potency, well-absorbed multivitamins help maintain telomere length.
The results suggest a link between genetic factors and social environment associated with changing telomere length, and suggests a potential biomarker for chronic stress exposure in children as young as 9 years of age, according to the authors.
The rate of shortening or the shortest telomere in a cell may be what's really important, not the average length of a person's telomeres," says Felipe Sierra, director of the Division of Aging Biology at the National Institute on Aging in Bethesda, Maryland.
The findings are based on a study of telomeres, protective caps on the ends of chromosomes that shorten as we age.