(redirected from Tetracyclin)
Also found in: Dictionary, Thesaurus, Medical.
Related to Tetracyclin: Tetracycline antibiotics


(tĕ'trəsī`klēn), any of a group of antibiotics produced by bacteria of the genus Streptomyces. They are effective against a wide range of Gram positive and Gram negative bacteria, interfering with protein synthesis in these microorganisms (see Gram's stainGram's stain,
laboratory staining technique that distinguishes between two groups of bacteria by the identification of differences in the structure of their cell walls. The Gram stain, named after its developer, Danish bacteriologist Christian Gram, has become an important tool
..... Click the link for more information.
). Tetracycline is used to treat rickettsial bacterial infections such as Rocky Mountain spotted fever, some eye, respiratory, intestinal, and urinary infections, some kinds of acne, and some diseases where the infecting microorganism is resistant to penicillinpenicillin,
any of a group of chemically similar substances obtained from molds of the genus Penicillium that were the first antibiotic agents to be used successfully in the treatment of bacterial infections in humans.
..... Click the link for more information.
 (see drug resistancedrug resistance,
condition in which infecting bacteria can resist the destructive effects of drugs such as antibiotics and sulfa drugs. Drug resistance has become a serious public health problem, since many disease-causing bacteria are no longer susceptible to previously
..... Click the link for more information.
). Tetracycline may cause permanent discoloration of developing teeth, and it is not given to pregnant and lactating women and growing children. Because of the development of strains of microorganisms resistant to the tetracyclines, these antibiotics have lost some of their usefulness. Aureomycin is a trade name for the derivative chlortetracycline, and Terramycin is a trade name for oxytetracycline.



any of a group of natural and semisynthetic antibiotics of similar chemical structure and biological action. In terms of chemical structure, tetracyclines are a tetracyclic condensed system with various substituents.

The natural tetracyclines—oxytetracycline (terramycin), chlortetracycline (aureomycin), and tetracycline—were discovered and isolated in the 1940’s and 1950’s from the metabolic products of such actinomycetes as Actinomyces rimosus and A. aureofaciens. (In the non-Soviet literature, the genus Actinomyces is called Streptomyces.)

Preparations obtained by the chemical modification of natural tetracyclines, as well as semisynthetic derivatives of tetracycline, are also used in medicine. Examples of the first group are Reve-rin, morphocycline, and glycocycline; among the members of the second are methacycline hydrochloride (Rondomycin), doxycycline (Vibramycin), and minocycline.

Tetracyclines are broad-spectrum antibiotics. They inhibit the growth of gram-positive and gram-negative bacteria, spirochetes, leptospires, rickettsiae, mycoplasmas, several protozoans (amoe-bas and trichomonads), and large viruses of the psittacosis-lym-phogranuloma and trachoma groups. They are inactive or only slightly active against Proteus, Pseudomonas aeruginosa, Mycobacterium tuberculosis, and most fungi and small viruses. The bacteriostatic action of tetracyclines results from the repression of protein biosynthesis in the bacterial cell.

The development of resistance to one of the tetracyclines is accompanied by resistance to all other tetracyclines except minocycline. Preparations combining tetracyclines with antibiotics having a different mechanism of antimicrobial action, such as oleandomycin, are used to prevent the propagation of strains resistant to tetracycline.

Tetracyclines are used for the treatment of diseases of the respiratory organs and the gastrointestinal, urinary, and biliary tracts, as well as infections of the soft tissues, epidemic typhus, and other diseases caused by microorganisms sensitive to these drugs. Tetracyclines are effective in infections caused by microorganisms that are resistant to other antibiotics.


Chernukh, A. M., and G. Ia. Kivman. Antibiotiki gruppy tetratsiklinov. Moscow, 1962.
Barton, D. H. R. “Novye puti sinteza tetratsiklina.” Zhurnal Vses. khimicheskogo obshchestva im. D. I. Mendeleeva, 1971, vol. 16, no. 2.
Navashin, S. M., and I. P. Fomina. Spravochnik po antibiotikam, 3rd ed. Moscow, 1974.
Finland, M. “Twenty-fifth Anniversary of the Discovery of Aureomycin: The Place of the Tetracyclines in Antimicrobial Therapy.” Clinical Pharmacology and Therapeutics, 1974, vol. 15, no. 1.



Any of a group of broad-spectrum antibiotics produced biosynthetically by fermentation with a strain of Streptomyces aureofaciens and certain other species or chemically by hydrogenolysis of chlortetracycline.
C22H24O8N2 A broad-spectrum antibiotic belonging to the tetracycline group of antibiotics; useful because of broad antimicrobial action, with low toxicity, in the therapy of infections caused by gram-positive and gram-negative bacteria as well as rickettsiae and large viruses such as psittacosis-lymphogranuloma viruses.
References in periodicals archive ?
2% resistance to oxacilin and tetracyclin, 43% to erythromycin, 100% sensitive to vancomycin.
3 (IPP) + 3019 Cebmk-I (KIF11) - 585 B[pounds sterling]KIF3B/Ca - 590 BfKIF3B/Cb - 610 BtTetrResa - 25846 BfTetrResb + 21359 BfVPS8a + 4869 BtVPS8b - 20941 BflppAa - 797 BflppAb - 805 BfKIFlla - 142 BfKIFllb - 145 Ci KIF3B + 21809 Ci TetrRes - 1647 Ci VPS8 - 585 Ci IppA + 12889 CiKIFll + 17516 * TetrRes, tetracyclin resistance; Ipp, inositol phosphatase.
5 fold respectively and also than Tetracyclin (30 [micro]g) and Amoxixicillin (10 pg) which showed no antibacterial activity against A.
71%) amikacin resistant whereas all strains were sensitive to ciprofloxacin, tetracyclin, linezolid and vancomycin.
Antibiotic discs of kanamycin (30ug), streptomycin (30ug), chloramphenicol (30ug), ampicillin (30ug), amoxilin (30ug), bacitracin (30ug), oxytetracyclin 30 ug) tetracyclin (30ug) and erythromycin (30 ug) were placed on thesurface of solid culture and then incubated at 37degC for 20 to 22 h.
articulatum; SD, standard deviation; Gent, gentamicin; Tet, tetracyclin Table I.
Of the 40 broiler isolates, 20 were resistant to [greater than or equal to]1 of the antimicrobial drugs tested (Table); only 1 was multidrug resistant (resistant to streptomycin, tetracyclin, sulfamethoxazole, and trimethoprim).
aeruginosa ATCC 15442 (mm[+ or -]SD %) Gentamicin Enhancement Tetracyclin Enhancement (%) (%) Not 14[+ or -]1.
The use of tetracyclin, once a favoured antibiotic to treat gonorrhoea, has been severely reduced because resistance has been found in nearly four in 10 patients.
Tetracyclin 10mg/disc also show the significant antibacterial activity against all the test bacteria.
All cry4 positive Bt isolates and positive controls of cry4 gene IPS78 and HD500 were found resistant to ampicillin, amoxicillin and bacitracin and were sensitive to chloramphenicol, erythromycin, kanamycin, neomycin, nalidixic acid, oxytetracyclin, polymixin, streptomycin, tetracyclin and vancomycin.