In vitro studies have shown the ability of pro-inflammatory stimuli to upregulate the steroidogenic enzyme responsible for androgen production in ovarian theca cells
Increased transcription and increased messenger ribonucleic acid (mRNA) stability contribute to increased GATA6 mRNA abundance in polycystic ovary syndrome theca cells
Insulin resistance directly contributes to androgenic potential within ovarian theca cells
After incubation, the theca cells
were stored at -20[degrees]C.
Insulin-sensitizers have a positive effect in PCOS patients through normalization of hyperinsulinaemia that otherwise amplifies the excessive androgen production from the ovary theca cells
via CYP17 phosphorylation and lower levels of SHBG.
In addition, there was no significant difference between COCs of small and large antral follicles, but mural granulosa cell / theca cell
complexes from large antral follicles had higher levels of mRNA for inhibin-[beta]A subunit than those from small antral follicles (P < 0.
Rare theca cells
were seen scattered in between the neoplastic granulosa cells.
3Rd, Guffey TA, Malkasian GD et al: Clinicopathologic review of 118 granulosa and 82 theca cell
In relation, the ES decline in S3 suggested that sub-chronic exposure could disrupt the ES synthesis of theca cells
in the ovarian follicles, and the following increase in S4 and S5 confirmed that ES production improved during the recovery period.
Angiotensin II reverses the inhibitory action produced by theca cells
on bovine oocyte nuclear maturation.
Recent studies showed that hyperandrogenism may also be due to local inflammatory response of ovarian theca cells
to reactive oxygen species  or to cytokines and chemokines produced by dysfunctional adipose tissue .