Thorpe reaction


Also found in: Wikipedia.

Thorpe reaction

[′thȯrp rē‚ak·shən]
(organic chemistry)
The reaction by which, in presence of lithium amides, α,ω-dinitriles undergo base-catalyzed condensation to cyclic iminonitriles, which can be hydrolyzed and decarboxylated to cyclic ketones.
References in periodicals archive ?
We now have the strong potential for a Thorpe reaction (ref.