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thrombolytic drug
(redirected from thrombolytic therapy)

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.04 sec.
thrombolytic drug (thrŏm'bəlĭt`ĭk) or clot-dissolving drug, substance, such as streptokinase or tissue plasminogen activator (tPA), that causes the breakdown of blood clots (see thrombosis thrombosis (thrŏmbō`sĭs), obstruction of an artery or vein by a blood clot (thrombus).
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) that obstruct the flow of blood through the vessels. Its uses include injection during or shortly after a heart attack or stroke stroke, destruction of brain tissue as a result of intracerebral hemorrhage or infarction caused by thrombosis (clotting) or embolus (obstruction in a blood vessel caused by clotted blood or other foreign matter circulating in the bloodstream); formerly called
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 (see infarction myocardial infarction or heart attack is usually caused by a blockage in one of the coronary arteries that supply blood to the heart muscle. The blockage typically occurs when a blood clot (see thrombosis ) lodges in an area already narrowed by arteriosclerosis ; other
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) to prevent clots from blocking blood flow to the heart muscle or brain.

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Regional infusion of thrombolytic therapy has been suggested as the best way to treat these patients.
Number needed to treat estimates incorporating effects over the entire range of clinical outcomes: novel derivation method and application to thrombolytic therapy for acute stroke.
Certain patients are not candidates for thrombolytic therapy because of a history of bleeding ulcer, recent stroke, trauma, or surgery.
 
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