thrombolytic drug


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Related to thrombolytic drug: Anticoagulant drug

thrombolytic drug

(thrŏm'bəlĭt`ĭk) or

clot-dissolving drug,

substance, such as streptokinase or tissue plasminogen activator (tPA), that causes the breakdown of blood clots (see thrombosisthrombosis
, obstruction of an artery or vein by a blood clot (thrombus). Arterial thrombosis is generally more serious because the supply of oxygen and nutrition to an area of the body is halted.
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) that obstruct the flow of blood through the vessels. Its uses include injection during or shortly after a heart attack or strokestroke,
destruction of brain tissue as a result of intracerebral hemorrhage or infarction caused by thrombosis (clotting) or embolus (obstruction in a blood vessel caused by clotted blood or other foreign matter circulating in the bloodstream); formerly called apoplexy.
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 (see infarctioninfarction,
blockage of blood circulation to a localized area or organ of the body resulting in tissue death. Infarctions commonly occur in the spleen, kidney, lungs, brain, and heart.
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) to prevent clots from blocking blood flow to the heart muscle or brain.
References in periodicals archive ?
The term 'pharmaco-mechanical thrombectomy' (PMT) refers to a combination of percutaneous mechanical thrombectomy and the local use of low doses of thrombolytic drugs introduced through the catheter during the procedure.
Thrombolytic drugs can cause serious bleeding and before they are given paramedics must be reasonably sure of the diagnosis.
With appropriate test chemistry, LOT provides a measure of in vitro fibrinolytic effects before the administration of a thrombolytic drug [6].
Tod Engelhardt, cardiothoracic surgeon from East Jefferson General Hospital (New Orleans, LA) added that, "Faster response with less thrombolytic drug means patients may recover within hours and the risk of bleeding is substantially reduced.
Streptokinase is not widely used as a thrombolytic drug in the United States.
SAN ANTONIO - When intravenous thrombolysis fails to dissolve a brain clot, intraarterial delivery of the thrombolytic drug might do the trick.
Division of Interventional Neuroradiology and UCLA Stroke Center, Ronald Reagan UCLA Medical Center, Los Angeles, CA stated, "In the US, roughly 50% of acute stroke interventions are performed with clot retrievers, and the remainder from a combination of angioplasty, clot aspiration, stenting, and thrombolytic drug delivery.
The drug should not be used in patients who have been recently treated with a platelet inhibitor, a thrombolytic drug, or in those who have undergone full anticoagulation with warfarin.
in the April publication of JVIR which reported EKOS-treated patients received half the thrombolytic drug dose or were treated in half the time, or both, when compared to recent historical experience with standard non-ultrasound catheter directed thrombolysis (CDT).
The standard thrombolyticdrug cocktail should no longer simply be the thrombolytic drug (usually a plasminogen activator) and unfractionated heparin.
SonoLysis + tPA therapy combines the Company's proprietary MRX-801 microbubbles, ultrasound and the thrombolytic drug tPA.
Ultrasound devices enable dissolution of blood clots by directing ultrasound energy alone, combining ultrasound with a thrombolytic drug, or by triple therapy of ultrasound, drug and microbubble agent to accelerate the therapeutic effect.