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Thyroglobulin

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thyroglobulin [¦thī·rō′gläb·yə·lən]
(biochemistry)
An iodinated protein found as the storage form of the iodinated hormones in the thyroid follicular lumen and epithelial cells.
Thyroglobulin 

a glycoprotein produced by the follicles of the thyroid gland; a direct precursor of the thyroid hormones. The carbohydrate and protein constituents of thyroglobulin are synthesized in the ribosomes of the thyroid epithelium. Subsequent iodination of the residues of the amino acid tyrosine, which are part of the thyroglobulin molecule, results in the formation of thyroxine and triiodothyronine. These are released into the blood after splitting off from thyroglobulin under the influence of the proteolytic enzymes of the thyroid gland. The cells’ ability to iodinate thyroglobulin arises after the appearance of the endoplasmic reticulum in the gland, the formation of follicles, and the secretion of thyrotropin by the hypophysis.
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Assessment methods include urinary iodine concentration, goitre, newborn thyroid-stimulating hormone, and blood thyroglobulin.
Iodine-deficiency disorders by Life Extension
After the operation, all patients underwent neck ultrasonography and serum thyroglobulin tests at three- and six-month intervals.
New robot-assisted surgical method successfully treats thyroid cancer by Asian News International
Building the thyroxine molecule needs three components--iodine, thyroglobulin and thyroperoxidase.
Thyroid disease and oral health by Roggow, Sandi / Access
 
 
 
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