tight junction

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tight junction

[¦tīt ′jəŋk·shən]
(cell and molecular biology)
An intercellular junction composed of a series of fusions of the junctional membrane, forming a continuous seal; serves as a selective barrier to small molecules and as a total barrier to large molecules. Also known as impermeable junction; occluding junction; zonula occludens.
References in periodicals archive ?
We have shown that distinct components of these blood vessels termed tight junctions are altered in Alzheimer's disease.
Dr James Keaney, who spearheaded the Trinity study, said: "We have shown that distinct components of these blood vessels termed tight junctions are altered in Alzheimer's disease.
The truck will be used as a gritter lorry in an urban area where there are narrow streets with tight junctions.
In the small intestine, the macromolecules cannot permeate through tight junctions of the intestinal cell wall because of multiple factors, including molecular size and steric hindrance effects, and are vulnerable to further enzymatic and hydrolytic degradation.
NEW YORK, June 25, 2015 /PRNewswire/ -- Epithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes.
In a microbiome that is off balance, the microvilli and the tight junctions found in the small intestine are not functioning properly.
In the gastrointestinal portion of the alimentary tract, tight junctions between the simple columnar epithelial cells of the mucosa serve as a selectively permeable barrier.
The observations from in vitro Caco-2 cell showed that the absorption of phenylethanoid glycosides in Fructus Forsythiae extract so with that in monomers was mainly restricted by the tight junctions, and influenced by efflux transporters (P-gp and MRP2).
Tight junctions (TJs) are cell-cell adhesion belts that encircle epithelial and endothelial cells at the limit between the apical and lateral membrane (Fanning, A.
The 23 papers cover molecular properties of the tight junction; regulation of the tight junction and barrier function; and tight junctions in skin, lung, endothelia, and nervous tissues.