tight junction

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tight junction

[¦tīt ′jəŋk·shən]
(cell and molecular biology)
An intercellular junction composed of a series of fusions of the junctional membrane, forming a continuous seal; serves as a selective barrier to small molecules and as a total barrier to large molecules. Also known as impermeable junction; occluding junction; zonula occludens.
References in periodicals archive ?
Tight junctions (TJs) are the apical-most adhesive multiple protein complexes that link the apical side of intestinal epithelial cells (IECs) preventing the diffusion of antigens freely across the epithelium.
We propose to address the hypothesis that it is possible to develop a radical approach to management of intraocular pressure employing an V-mediated system for increasing the permeability of Schlemms canal endothelial cells (SCEC), based on published supportive data from this laboratory showing that RNAi-mediated down regulation of mRNA encoding components of tight junctions of neuronal vascular endothelia induces increased cell permeability, a process which has been used to validate a procedure for acute treatment of neuronal edema.
Looking more closely, the researchers determined that insulin was disrupting tight junctions between retinal pigment cells (RPEs), the barrier layer wrapped around retinal nerves, by driving up BTC expression.
According to our previous study, the intestinal absorption mechanism of FTA was passive diffusion, and involved paracellular route transport mainly governed by the tight junctions (TJs) (Zhou et al.
While the upper-most layer of the skin - the stratum corneum - has been pinned as the culprit in previous research, a new study has found that a second skin barrier structure, consisting of cell-to-cell connections known as tight junctions, is also at fault and plays a role in the development of the disease.
KEY WORDS: blood-brain barrier, brain metastasis, polychlorinated biphenyls, tight junctions.
Numerous studies have shown that the intercellular junctions and, in particular, the tight junctions regulate the permeability of the paracellular spaces and limit "water leakage.
Septate and tight junctions (SJs and TJs, respectively) are included under one category because they are thought to serve analogous roles in the taxa they are found in, although their molecular composition and evolutionary origin may differ.
Normally, the gut has a healthy barrier, which includes a mucus layer and a layer of cells that are connected by tight junctions, acting like doorways that allow nutrients from food to be transported out of the gut and into the blood stream.
The researchers found that the cells in the model had successfully differentiated into a mature epithelium layer with all four of the major intestinal cell types and displayed important small intestine characteristics such as tight junctions, polarized microvilli, and secretion of digestive enzymes.
Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cells.