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Related to Toluidine: Toluidine blue



any of three amino derivatives of toluene.

Ortho, meta, and para isomers of toluidines are known (see Table 1). Toluidines are readily soluble in organic solvents but poorly soluble in water; they may be steam-distilled, and they darken (oxidize) upon storage in light in the presence of air.

Toluidines are obtained industrially by the reduction of nitro-toluenes using iron and hydrochloric acid. They are similar to aniline in their chemical properties. They form salts with acids and

Table 1. Selected properties of toluidines
 Melting point (°C)Boiling point (°C)Density at 20°C (g/cm3)
Ortho-toluidine(1,2-). . . . . . . . . .–24,4 (unstable)200.30.9984
Ortho-toluidine (1,6-). . . . . . . . . .–16.25 (stable)200.30.9984
Mete-toluidine(1,3-or 1,5-). . . . . . . . . .–30.4203.40.9891
Para-toluidine (1,4-). . . . . . . . . .44.5–45,0200.551.046

undergo diazotization, acylation, halogenation, sulfonation, and alkylation. Toluidines are used in the manufacture of various dyes.


References in periodicals archive ?
NASDAQ:ZILAD) today announced encouraging preliminary results of an in vivo animal study which showed evidence of photodestruction of premalignant lesions and squamous cell carcinoma when treated with Zila's patented pharmaceutical grade toluidine blue, both a diagnostic adjuvant and a photosensitizer for DMBA-induced precancers and cancers in the hamster cheek pouch model.
The mass was composed of vascular spaces with scattered mast cells showing metachromatic reaction with toluidine blue stain.
The cell walls reacted positively to the PAS and Toluidine Blue, showing the degradation of the wall, from a defined, rigid structure in the first days of germination (t0 to t6, Figures 3a-d and 4a-d, respectively) to a flaccid one, causing a loss in structure integrity, observed in the late periods of germination (t8 to t10, Figures 3e-f and 4e-f, respectively).
However, because Doe (1976) noted that the hook supports contain glandular tissue, which may also stain with toluidine blue/basic fuchsin, we examined the putative tensile connective tissue elements with transmission electron microscopy for electron-dense extracellular matrix (Fig.
Similarly prepared and stained sections as for light microscopy, and which had been stained with Toluidine Blue, were examined with confocal laser scanning microscopy.
7) Sections were stained with hematoxylin-eosin, May-Grunwald-Giemsa, periodic acid-Schiff, toluidine blue, silver-nitrate-methenamine, and Alcian blue.
Toluidine blue stain: Lesions in the mouth are coated with a blue dye.
Disks plate toluidine blue to count staphylococcus aureus.
Toluidine blue staining and Giemsa staining techniques were used in the present study for the demonstration of Pneumocystis carinii in the sputum.