Toluidine


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Related to Toluidine: Toluidine blue

Toluidine

 

any of three amino derivatives of toluene.

Ortho, meta, and para isomers of toluidines are known (see Table 1). Toluidines are readily soluble in organic solvents but poorly soluble in water; they may be steam-distilled, and they darken (oxidize) upon storage in light in the presence of air.

Toluidines are obtained industrially by the reduction of nitro-toluenes using iron and hydrochloric acid. They are similar to aniline in their chemical properties. They form salts with acids and

Table 1. Selected properties of toluidines
 Melting point (°C)Boiling point (°C)Density at 20°C (g/cm3)
Ortho-toluidine(1,2-). . . . . . . . . .–24,4 (unstable)200.30.9984
Ortho-toluidine (1,6-). . . . . . . . . .–16.25 (stable)200.30.9984
Mete-toluidine(1,3-or 1,5-). . . . . . . . . .–30.4203.40.9891
Para-toluidine (1,4-). . . . . . . . . .44.5–45,0200.551.046

undergo diazotization, acylation, halogenation, sulfonation, and alkylation. Toluidines are used in the manufacture of various dyes.

B. L. DIATKIN

References in periodicals archive ?
Sections were prepared and stained with Toluidine Blue, as described in the Light Microscopy section.
Types of pigments: Blacks (Carbon Black Dispersions); Blues (Indanthrone blue, Phthalocyanine Blue); Corrosion inhibiting (Zinc Flake, Zinc Paste); Greens (Phthalocyanine green); Metallic Pigments (Aluminum paste, Aluminum powder, Waterborne Aluminum, Stain resistant Aluminum, GoldBronze powders); Reds (Bon Red/Maroon, Lithol Rubine, Naphthol, Perylene Red, Perylene Maroon, Perylene Scarlet, Perylene Violet, Quinacridone Maroon, Quinacridone Red, Quinacridone Scarlet, Diketo-pyrrolo-pyrrole Red, Dioxazine Violet, Toluidine Red); Yellows and Oranges (Diarylide Yellow, Diarylide Orange, Hansa Yellow, Azo Yellow, Isoindoline Yellow, Benzimidazalone Yellow, Benzimidazalone Orange, Perinone Orange)
Zila(R) Tolonium Chloride (ZTC(TM)) is a patented composition of matter that is designed to be superior to traditional toluidine blue.
The lesions that were deemed suspicious were then assessed with Vizilite, followed by the toluidine blue dye and then biopsied.
Zila's Chairman, President and CEO, confirmed that the article indicates that the toluidine blue used in the Canadian study is the Company's proprietary Zila(R) Tolonium Chloride (ZTC(TM)).
markets pharmaceutical, biomedical, dental and nutritional products to professionals and consumers through seven operating groups: Zila Biomedical is introducing OraTest(R) worldwide; Zila Manufacturing produces the only pharmaceutical-grade toluidine blue -- Zila(R) Tolonium Chloride; Zila Pharmaceuticals markets prescription and non-prescription oral healthcare products; Zila Dental Supply is a national dental supplies distributor; PracticeWorks markets proprietary dental practice management software; Cygnus Imaging manufactures and markets intraoral video camera and digital x-ray systems; and Oxycal Laboratories supplies Ester-C(R) vitamin products worldwide.
Pigments Offered: Blacks (carbon black); Blues (phthalocyanine); Greens (phthalocyanine); Reds (arylide red/maroon, BON red/maroon, lithol rubine, metallized azo red, naphthol red, quinacridone red, quinacridone violet, red Lake C, toluidine red); Yellows and Oranges (diarylide orange toner, diarylide yellow toner, hansa yellow, metallized azo yellow, dinitraniline orange).
ViziLite Plus combines the oral screening technology of ViziLite, an advanced chemiluminescent light technology, with TBlue630, a marking system using Zila(R) Tolonium Chloride (ZTC(TM)), the only patented pharmaceutical-grade form of toluidine blue used in marking lesions identified during a ViziLite examination.
Autoradiograms were developed, stained with toluidine blue, and examined in a Leica (DM RXE) light microscope.
markets pharmaceutical, biomedical, dental and nutritional products to professionals and consumers through 7 operating groups: Zila Biomedical is introducing the OraTest(R) oral cancer detection system worldwide; Zila Manufacturing produces the only pharmaceutical-grade toluidine blue -- Zila(R) Tolonium Chloride; Zila Pharmaceuticals markets prescription and non-prescription oral healthcare products; Zila Dental Supply is a national dental supplies distributor; PracticeWorks markets proprietary dental practice management software; Cygnus Imaging manufactures and markets intraoral video camera and digital x-ray systems; and Oxycal Laboratories supplies Ester-C(R) vitamin products worldwide.
Blacks (carbon black); Blues (indanthron blue, phthalocyanine blue); Greens (phthalocyanine green); Iron oxide pigments (yellow); Reds (BON red, lithol rubine, metallized azo red, napthol red, perylene maroon, perylene red, pigment scarlet, pyrazolone red, qainacridone red, quinacridone violet, red lake C, toluidine red); Yellow and Oranges (Diarylide orange toner, diarylide yellow toner, Hansa yellow, metallized azo yellow, orthonitraniline orange, dinitraniline orange).
Independent clinical research reported in the May issue of the Journal of Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics demonstrated that toluidine blue is "highly reliable in the detection of in situ carcinoma and invasive squamous cell carcinoma, because false-negative results for the lesions did not occur.