Transaminase


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Related to Transaminase: Lactic acid dehydrogenase, Aspartate transaminase

transaminase

[¦tranz′am·ə‚nās]
(biochemistry)
One of a group of enzymes that catalyze the transfer of the amino group of an amino acid to a keto acid to form another amino acid. Also known as aminotransferase.

Transaminase

 

(also aminotransferase and aminopherase), an enzyme of the transferase group that catalyzes the transfer of an amino group (—NH2) from an α-amino acid to an α-keto acid. Transaminases are found in most animal and plant tissues and play an important part in nitrogen metabolism. The role of transaminase in the transamination process was discovered by the Soviet biochemists A. E. Braunshtein and M. G. Kritsman in 1937. The coenzyme in transaminase reactions is pyridoxal phosphate, the aldehyde group of which serves as intermediate acceptor of the amino group. The resulting pyridoxamine phosphate transfers the amino group to the ketone group of the acid undergoing amination. The reaction is reversible.

A. A. BOLDYREV

References in periodicals archive ?
Conclusion: Discrimination between hepatitis A and B in acute phase using serum transaminase concentrations could be helpful to get isolation precautions and to plan supportive therapy in early phase.
Emphasis should be given in excluding other etiologies of elevated bilirubin and transaminases, such as acute hepatitis A, B or C, HIV or other less common viral hepatitides.
8 mg/dL), and an alkaline phosphatase of 496 IU/L; transaminase levels were falling.
Glutamate oxaloacetate transaminase (GOT): The GOT activity level increased by 20% in tolzan treated worms, as compared to control worms.
The serum samples were subjected to assay for hepatic marker enzymes such as aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP).
She had discontinued interferon primarily because it had elevated her liver transaminase levels.
ITALY--Elevated serum transaminase levels are often found in patients who do not have diabetes or dyslipidemias, but the clinical significance of "nonalcoholic fatty liver disease" is not clear.
The Precautions section was revised to provide additional information about possible cholesterol, triglyceride and liver transaminase elevations when amprenavir is co-administered with ritonavir.
Reduction of glutamic pyruvic transaminase in pyridoxine deficiency in liver disease.
Serial transaminase measurements provide a noninvasive means of estimating the severity of hepatitis C virus infection in infected renal transplant recipients and make liver biopsy unnecessary, according to researchers at the University of Istanbul, Turkey.
Patients with nevirapine-related hepatotoxicity may complain of fatigue, malaise, anorexia and nausea with or without elevated transaminase levels.