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Transaminase
(redirected from Transaminases)

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.01 sec.
transaminase [¦tranz′am·ə‚nās]
(biochemistry)
One of a group of enzymes that catalyze the transfer of the amino group of an amino acid to a keto acid to form another amino acid. Also known as aminotransferase.

Transaminase 

(also aminotransferase and aminopherase), an enzyme of the transferase group that catalyzes the transfer of an amino group (—NH2) from an α-amino acid to an α-keto acid. Transaminases are found in most animal and plant tissues and play an important part in nitrogen metabolism. The role of transaminase in the transamination process was discovered by the Soviet biochemists A. E. Braunshtein and M. G. Kritsman in 1937. The coenzyme in transaminase reactions is pyridoxal phosphate, the aldehyde group of which serves as intermediate acceptor of the amino group. The resulting pyridoxamine phosphate transfers the amino group to the ketone group of the acid undergoing amination. The reaction is reversible.

A. A. BOLDYREV



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However, transaminases are now elevated and histologically there is increased necroinflammatory activity.
The importance of this topic was also highlighted by the findings of a recent study presented at this year's Conference on Retroviruses and Opportunistic Infections in Montreal showing a high prevalence of hepatic fibrosis and steatosis in HIV/AIDS patients without chronic viral hepatitis but with chronically elevated transaminases on antiretroviral therapy [5].
The most frequent side effects related to the use of statins, myopathy, rhabdomyolysis, and increased levels of transaminases, are unusual.
 
 
 
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