transketolase


Also found in: Medical, Acronyms, Wikipedia.

transketolase

[¦tranz′kēd·ə‚lās]
(biochemistry)
An enzyme that cleaves a substrate at the position of the carbonyl carbon and transports a two-carbon fragment to an acceptor compound to form a new compound.
Mentioned in ?
References in periodicals archive ?
This was similar to a study conducted by Alkhalaf which showed decreased levels of plasma thiamine and transketolase in Dutch diabetic population16.
The study demonstrated that the fundamental defect in TRMA is impaired transketolase activity, which subsequently leads to decreased nucleic acid synthesis and disruption of the cell's normal progression through the cell cycle (Boros et al.
Pearson's product moment correlation coefficient was calculated to measure the association between the maternal and infant transketolase [alpha] values and the fatty acid levels.
It activates a vital enzyme called transketolase, which converts toxic glucose-induced metabolites into harmless compounds.
Benfotiamine increases the production of thiamine pyrophosphate, which increases transketolase activity; transketolase blocks glucose-induced damage by preventing AGE formation.
These latter ORFs are not conserved among cycloviruses and show low partial homology to bacterial enzymes, NAD-dependent DNA ligase of Psychrobacter (ORF3), transketolase of Sinorhizobium (ORF4), and dTDP-D-glucose 4,6-dehydratase of Actinomyces (ORF5).
This may be done by the activation of reductive pentose phosphate pathway (PPP) by high-dose thiamine therapy that would increase transketolase (TK) activity and stimulate the conversion of glyceraldehyde-3-phosphate (GA3P) and fructose-6-phosphate (F6P) to ribose-5-phosphate (R5P), thus reducing the risk of the development of diabetic complications.
1) (ERP60) 100 WD repeat protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) 101 WD repeat protein 1 (Actin-interacting protein 1) (AIP1) 102 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial precursor 103 Transketolase (EC 2.
Transketolase occurs twice in the hexose monophosphate shunt and since this pathway occurs in erythrocytes it is used to test for biological evidence of thiamine deficiency (1).
Vitamin B(1) status assessed by direct measurement of thiamin pyrophosphate in erythrocytes or whole blood by HPLC: comparison with erythrocyte transketolase activation assay.