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The zymogen of trypsin, secreted in the pancreatic juice. Also known as protrypsin.



an inactive precursor (proenzyme) of the proteolytic enzyme trypsin. Trypsinogen is synthesized in the pancreas and converted into trypsin—the active enzyme—in the small intestine. The activation of trypsinogen entails the cleavage of a short peptide fragment from the N-terminal of the trypsinogen molecule by the enzyme enterokinase or by trypsin itself.

References in periodicals archive ?
In this case, says Logsdon, part of a working protein arose from a bit of the trypsinogen gene that does not code for protein.
In the Arctic cod, in contrast, the researchers' analysis of the antifreeze protein doesn't show the same sequences of bases from the trypsinogen gene, even though the protein is made up of the same three ice-binding amino acids.
Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl.
Combining immunoreactive trypsinogen and pancreatitis-associated protein assays, a method of newborn screening for cystic fibrosis that avoids DNA analysis.
Of the assays for these 2 trypsinogens, the assay for urine trypsinogen-2 has gained the most interest (15), but mixed results have hampered its routine implementation (16).
Premature activation of trypsinogen within the pancreas is thought to play an important role in development of acute pancreatitis (AP) [6] (4).
In the present study, we report development of a suspension array multiplexed immunoassay for the 2 specific isoforms of trypsinogen, IRT1 and IRT2.
A transgenic mouse model expressing the Arg122His mutation in mouse trypsinogen displayed early-onset acinar injury, inflammatory cell infiltration, and enhanced response to cerulein-induced pancreatitis (21).
If trypsinogen is prematurely activated in the pancreas, PSTI serves as a first line of defense by preventing further activation of other pancreatic enzymes, which can eventually lead to development of pancreatitis (3).
Neonatal screening for cystic fibrosis using immunoreactive trypsinogen and direct gene analysis: four years' experience.
In March 2002, DNA testing of the top 4% of the daily immunoreactive trypsinogen results expanded to include a1125 mutations recommended by the American College of Medical Genetics, the American College of Obstetricians and Gynecologists, and the NIH.
With the addition of a bead-based test for 17-hydroxyprogesterone, the serum marker for congenital adrenal hyperplasia, and immunoreactive trypsinogen, the serum marker for cystic fibrosis, to the [T.