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(also called scrub typhus), an acute disease of man; a naturally endemic rickettsiosis. The reservoirs of the causative agent are rats, microtines, and mites of the superfamily Trombea. Tsutsugamushi occurs in Eastern and Southeast Asia and in Primor’e Krai in the USSR. A natural nidus of the disease exists in the Tadzhik SSR.

Tsutsugamushi develops after the victim is bitten by an infected mite. A small crusty ulcer appears on the site of the bite after an incubation period of 6–10 days. The disease sets in acutely with fever (39–40°C for 14–16 days), headaches, insomnia, muscular pain, and a bright red rash on the fifth to seventh days.

Serodiagnosis is used to detect the disease; treatment is by antibiotics. Preventive measures include the extermination of rats and insects in dwellings located in natural nidi of the disease, the use of mite repellents, and the wearing of protective clothing.


Zdrodovskii, P. F., and E. M. Golinevich. Uchenie o rikketsiiakh i rikketsiozakh, 3rd ed. Moscow, 1972.


References in periodicals archive ?
cytomegalovirus, Epstein-Barr virus [EBV]) or if serum testing results provided evidence of acute infection for pathogens known to be associated with encephalitis, such as Orientia tsutsugamushi, Bartonella henselae, and Mycoplasma pneumoniae.
tsutsugamushi was isolated from the bronchoalveolar lavage sample after 40 days of culture (Figure); 500 [micro]L of bronchoalveolar lavage fluid was used for culture.
tsutsugamushi from patients and rodents in different scrub typhus-endemic regions have been reported by testing using the 56-kDa TSA, which has led to identification of several new subtypes (1), such as Japanese Gilliam, Japanese Karp, Kawasaki, Kuroki, and Shimokoshi, in addition to the previously described prototypes Karp, Kato, and Gilliam (7,8).
tsutsugamushi was reported for 25% of scrub typhus patients in a study population in Thailand (7).
tsutsugamushi using commercial ELISA kit (InBios International, Inc.
Scrub typhus is a mite-borne infectious disease caused by Orientia tsutsugamushi.
Trombiculid mites of China: study on vector and pathogen of tsutsugamushi disease.
Second, the scrub typhus-causing genus Orientia, which only contains one recognized species, Orientia tsutsugamushi.
prowazekii Metropolitan Pediculus Yes humanus Orientia Isla de Leech Yes tsutsugamushi Chiloe URUGUAY R.
Rickettsial diseases include spotted fever group (SFG) rickettsioses (Mediterranean spotted fever, African tick-bite fever and the typhus group of rickettsiae), scrub typhus caused by Orientia tsutsugamushi, human monocytic ehrlichiosis and human granulocytic anaplasmosis.