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tumor suppressor gene |
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tumor suppressor gene [¦tüm·ər sə′pres·ər jēn] (cell and molecular biology) A class of genes which, when mutated, predispose an individual to cancer by causing the loss of function of the particular tumor suppressor protein encoded by the gene. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The findings suggest the potential for a specific, single microRNA (miR-34a) to be used as a drug candidate in cancer therapy to increase programmed cell-death (apoptosis) in the context of the potent tumor suppressor p53. LKB1/STK11 encodes a protein that appears to be a tumor suppressor, but the protein's precise function remains unknown, she says. Molecular defects in both tumor suppressor genes and oncogenes have been pathogenically linked to melanoma in recent studies. |
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