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tumor suppressor gene |
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tumor suppressor gene [¦tüm·ər sə′pres·ər jēn] (cell and molecular biology) A class of genes which, when mutated, predispose an individual to cancer by causing the loss of function of the particular tumor suppressor protein encoded by the gene. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Previous research suggested that DCC acts as a tumor-suppressor gene because, as its name implies, it's frequently missing in people with colorectal cancer. Because of these properties, the p53 gene is known as a tumor-suppressor gene. A team headed by Ronald DePinho of Dana-Farber Cancer Institute in Boston has crossed the KRAS-mutant mice with mice lacking a tumor-suppressor gene implicated in pancreatic cancer. |
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