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tumor suppressor gene |
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tumor suppressor gene [¦tüm·ər sə′pres·ər jēn] (cell and molecular biology) A class of genes which, when mutated, predispose an individual to cancer by causing the loss of function of the particular tumor suppressor protein encoded by the gene. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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HDAC inhibitors act by turning on tumour suppressor genes that have been inappropriately turned off. This sensitization was shown to be achieved by the demethylation and reactivation of the tumour suppressor gene RASSF1A that was silenced by methylation in up to 90% of renal cancers. AustCancer's Pentrys(TM) vaccine technology is based on peptides derived from antibodies to the p53 tumour suppressor gene protein product. |
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