Like Rumex occidentalis, alpha-arbutin possesses strong inhibitory effects on tyrosinase
As to tyrosinase
inhibitor effects, the best inhibitory effect were observed in T-Me and F-W found to be inactive against tyrosinase
Quantification of tyrosinase
, TRP-1 and TRP-2 transcripts in human melanocytes by reverse transcriptase-competitive multiplex PCR--regulation by steroid hormones.
Immunohistochemical expression of melan-A and tyrosinase
in uveal melanoma.
Antibodies used in this study are the following: p-CREB (SC-101663), tyrosinase
(SC-15341), MITF (SC-11002), MMP1 (SC-12348), MMP9 (SC-6840), MMP12 (sC-30072) MMP13 (SC-12363), type 1 procollagen (SC-25973), type 3 procollagen (SC-8779), p-p65 (S536) (SC-33020), iNOS (SC-8310), [beta]-actin (SC-47778), and TFIIB (SC-225).
It stops tyrosinase
activity better than arbutin and Kojic acid, but it is more effective when combined with other agents like retinoids.
As a member of the Na+/H+ antiporter family the OCA2 protein is thought to play an essential role in maintaining the acid pH of the melanosomes which regulates the tyrosinase
2013) Isolation of long-chain esters from the rhizome of Polygonatum verticillatum by potent tyrosinase
, encoded by tyrosinase
(TYR) gene, is known to be the rate-limiting enzyme affecting the production of melanin pigment (Sanchez-Ferrer et al.
In addition, some authors have described a cross-reactive T cell response between tyrosinase
peptides and the CMV antigen in VKH patients.
Melanin is produced in the skin by the melanocytes through a series of oxidative reactions involving the amino acid tyrosine and the enzyme tyrosinase
The Merial vaccine uses human DNA to trigger a dog's immune system to detect one antigen (protein) found in melanoma cells--the protein tyrosinase
, which contributes to dark pigmentation.