Tyrosinase


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Related to Tyrosinase: tyrosine

tyrosinase

[′tir·ə·sə‚nās]
(biochemistry)
An enzyme found in plants, molds, crustaceans, mollusks, and some bacteria which, in the presence of oxygen, catalyzes the oxidation of monophenols and polyphenols with the introduction of ‒OH groups and the formation of quinones.

Tyrosinase

 

(ortho-diphenoloxidase), a enzyme of the oxidoreductase class that is present in almost all animals and plants. Tyrosinase catalyzes the oxidation of the amino acid tyrosine into dopa during the biosynthesis of melanins. It takes part in the synthesis of epinephrine and in other metabolic processes. Hereditary disruption of tyrosinase activity or the absence of tyrosinase causes albinism. Tyrosinase has been found to be identical to polyphenoloxidase.

References in periodicals archive ?
delta]T3 has been found to decrease melanin levels in mouse B16 melanoma cells by inhibiting the oxidative reactions of tyrosinase (Michihara et al.
Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: Implication of the microphthalmia gene product.
22] A recent study identified a potential therapeutic for OCA1 where some tyrosinase activity is present.
Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions.
Further, included in the concept that portrayed "tyrosine metabolism and melanin biosynthesis" were multiple protein-protein complexes involving the proteins Dopachrome tautomerase, Tyrosinase and Tyrosinase-related protein 1, all of which are copper binding proteins and play a critical role in the above bioprocess.
Since normal melanocytes are not thought to circulate in peripheral blood, detection of tyrosinase transcription should correlate to identification of CTCs (16, 17).
Vaccination with human tyrosinase DNA induces antibody responses in dogs with advanced melanoma.
2] may have decreased browning by increasing vacuolar membrane integrity, thereby reducing the opportunity for tyrosinase to react with its phenolic substrates.
We want it to be very toxic in tyrosinase-containing cells and completely non-toxic in cells that do not contain tyrosinase," she explains.
To determine the effectiveness of tropolone, PTU and DETC as specific inhibitors, we did preliminary experiments using PAGE gels loaded with mushroom tyrosinase or horseradish peroxidase (Sigma Chemical Co.
Alpha-Arbutin is much more effective in restraining tyrosinase, an enzyme that stimulates the formation of melanin, which can cause freckles, according to the company.