delta]T3 has been found to decrease melanin levels in mouse B16 melanoma cells by inhibiting the oxidative reactions of tyrosinase
(Michihara et al.
Regulation of tyrosinase
gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: Implication of the microphthalmia gene product.
22] A recent study identified a potential therapeutic for OCA1 where some tyrosinase
activity is present.
Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase
in human melanoma cell lines and in human melanocytic lesions.
Further, included in the concept that portrayed "tyrosine metabolism and melanin biosynthesis" were multiple protein-protein complexes involving the proteins Dopachrome tautomerase, Tyrosinase
-related protein 1, all of which are copper binding proteins and play a critical role in the above bioprocess.
Since normal melanocytes are not thought to circulate in peripheral blood, detection of tyrosinase
transcription should correlate to identification of CTCs (16, 17).
Vaccination with human tyrosinase
DNA induces antibody responses in dogs with advanced melanoma.
2] may have decreased browning by increasing vacuolar membrane integrity, thereby reducing the opportunity for tyrosinase
to react with its phenolic substrates.
We want it to be very toxic in tyrosinase
-containing cells and completely non-toxic in cells that do not contain tyrosinase
," she explains.
These plants contain compounds that inhibit an enzyme called tyrosinase
which controls melanin production.
To determine the effectiveness of tropolone, PTU and DETC as specific inhibitors, we did preliminary experiments using PAGE gels loaded with mushroom tyrosinase
or horseradish peroxidase (Sigma Chemical Co.
Alpha-Arbutin is much more effective in restraining tyrosinase
, an enzyme that stimulates the formation of melanin, which can cause freckles, according to the company.