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tyrosine hydroxylase |
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tyrosine hydroxylase [‚tī·rə‚sēn hī′dräk·sə‚lās] (biochemistry) A specialized enzyme located only in catecholamine-containing nerve cells, where it serves as the primary regulatory or rate-limiting step in catecholamine biosynthesis. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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They contrasted the effects on cell viability, DNA synthesis associated with cell replication, and increased expression of enzyme markers that characterize cholinergic or catecholaminergic phenotypes: choline acetyltranferase (CHAT) and tyrosine hydroxylase (TH), respectively. In test-tube studies, the scientists found that the phthalide compound blocks the action of an enzyme called tyrosine hydroxylase, which the body used to produce catecholamines. The neurons generated from the hES-derived precursors also synthesized neurotransmitters and a subpopulation expressed tyrosine hydroxylase. |
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