tyrosine hydroxylase


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Related to tyrosine hydroxylase: DOPA decarboxylase

tyrosine hydroxylase

[‚tī·rə‚sēn hī′dräk·sə‚lās]
(biochemistry)
A specialized enzyme located only in catecholamine-containing nerve cells, where it serves as the primary regulatory or rate-limiting step in catecholamine biosynthesis.
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Photomicrograph showing chief cells, which are focally immunoreactive for tyrosine hydroxylase (original magnification X20).
Role of phenol oxydases and tyrosine hydroxylase in control of dopamine content in Drosophila virilis under normal conditions and heat stress.
Abbreviations: ASO, apical sensory organ; 5-HT, serotonin; lir, like immunoreactive; TH, tyrosine hydroxylase.
Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation.
Tyrosine hydroxylase (TH) is the limiting enzyme in the synthesis of DA and is often used as a marker of DA neurons.
11,14) This might be due to a reduced expression of tyrosine hydroxylase and phenylethanolamine N-methyltransferase (enzyme that converts norepinephrine to epinephrine) in VHL-related pheochromocytomas.
When the parasite infects the brain, it forms a cyst and produces an enzyme called tyrosine hydroxylase, a building block of dopamine, the authors said (http://www.
Iron is a cofactor in tyrosine hydroxylase, the rate-limiting step in the conversion of tyrosine to dopamine.
In animal models of nigrostriatal injury, a two weeks treatment with platelet-derived growth factor-BB resulted in long-lasting restoration of striatal dopamine transporter binding sites and expression of nigral tyrosine hydroxylase," said Anders Haegerstrand, Chief Scientific Officer, NeuroNova AB, Stockholm, Sweden.
Melatonin attenuates tyrosine hydroxylase loss and hypolocomotion in MPTP-lesioned rats.
Activated forms of pyridoxine, niacin, iron, and tetrahydrobiopterin are cofactors for the enzymes tyrosine hydroxylase and tryptophan 5-hydroxylase, which participate in brain biosynthesis of catecholamines and serotonin.
They contrasted the effects on cell viability, DNA synthesis associated with cell replication, and increased expression of enzyme markers that characterize cholinergic or catecholaminergic phenotypes: choline acetyltranferase (CHAT) and tyrosine hydroxylase (TH), respectively.