2009), indicated that UCPs are under direct regulation by the VD/VDR signaling, furthermore, showed that VDR overexpression in the adipose tissue led to the suppression of UCP1
, UCP2, and UCP3 (Wong et al.
Bu calismanin sonucunda, beyaz yag dokusu ve iskelet kas dokusunda UCP2 gen ekspresyonun arttigi, kahverengi yag dokusunda ise UCP1
gen ekspresyonun arttigi rapor edilmis ve borik asidin bu sayede termogenezi arttirip, vucut agirliginda azalmayi saglayabilecegi bildirilmistir (31).
dissipates the proton motive force that is normally used to drive the synthesis of cellular adenosine triphosphate (ATP), releasing the energy in the mitochondrial electrochemical gradient in the form of heat.
Methods: We examined the effect of 8-week resistance exercise on plasma irisin levels and expression profiles of muscle FNDC5 and subcutaneous adipose tissue UCP1
in male rats.
Our early studies showed that mRNAs of UCP1
(Yuan et al.
Thyroid hormones induce an increase in the dedifferentiation of beige adipocytes through a direct regulation of UCP1
In the setting of hypoxia/reoxygenation, UCP1
overexpression confers cardioprotection .
action leads to dissipation of the proton gradient and the uncoupling of oxidative phosphorylation, thereby increasing heat production.
De los subtipos de adipocitos, los mas usados en experimentacion han sido el blanco y el pardo, los cuales se diferencian en su localizacion, morfologia (vacuola y organelas) y funciones; estas celulas se pueden caracterizar por la expresion de marcadores como la leptina, expresada primordialmente en el adipocito blanco y la UCP1
(uncoupled protein 1), expresada exclusivamente en los adipocitos pardos (18).
2] Nonstandard abbreviations: WAT, white adipose tissue; UCP1
, uncoupling protein 1; ASC-1, neutral amino acid transporter, y+ system, also called solute carrier family 7 member 10, slc7a10; PET/CT, positron emission tomography-computed tomography; PAT-2, proton/amino acid symporter member 2, also called solute carrier family 36 member 2, slc36a2; P2RX5, purinergic receptor P2X, ligand-gated ion channel 5.
Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1
expression in white adipose tissues.
Future studies on how PAF/PAFR signalling controls UCP1
levels through beta3-AR production in the BAT of animals and humans may reveal new therapeutic targets to treat metabolic disorders associated with obesity," Junko Sugatani, from the University of Shizuoka in Shizuoka, Japan, said.