vascular endothelial growth factor

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vascular endothelial growth factor

[¦vas·kyə·lər ‚en·dō¦thē·lē·əl ′grōth ‚fak·tər]
(medicine)
A soluble factor that acts through specific cell-surface receptors on endothelial cells to critically regulate vasculogenesis.
References in periodicals archive ?
Table 2 summarizes the HSCOREs of VEGF and Flk-1 in the endometrium during the menstrual cycle.
The fact that angiogenesis may have an important role in AML and the key regulatory role of the VEGF/VEGFR complex in angiogenesis leads to the performing of studies regarding the role of VEGF in AML (26-28).
On the third and seventh days postinjury, eight rats in each group were euthanized by chloroform inspiration and wound strips were removed along the incision, including 3 mm from the edges, and were used as tissue samples for examining skin VEGF protein.
Expression of the angiomatrix and angiogenic proteins CYR61, CTGF, and VEGF in osteonecrosis of the femoral head.
Vehicle (DMSO)-treated cells were used as a control in all of the experiments to provide baseline levels of VEGF production.
Because normal tissues were not available for comparison with tumor tissues, we measured circulating VEGF concentrations in the 3 ELISAs.
Due to critical role of VEGF in tumour growth and metastasis, targeting VEGF and VEGF receptor signaling in cancer treatment has been attempted with success using many approaches for various tumours.
The PRS-050 program has been designed to develop Anticalins(R) that specifically bind and block the signalling activity of VEGF.
VEGF is a powerful growth factor with a number of important effects including promotion of blood vessel growth and immune system function.
The Phase I trial is an open-label study in patients with advanced tumors and will evaluate the VEGF Trap in increasing dose levels.
Since HCC is a distinctively hypervascular tumor and angiogenesis is important in hepatocarcinogenesis,[13-15] and also since increased expression of VEGF has been reported in HCC,[16-20] we studied the degree of VEGF expression and its relationship to angiogenesis and the proliferation activity of hepatocytes and HCC cells in low-grade DNs, high-grade DNs, early HCCs, small HCCs, and advanced HCCs to understand the role of VEGF in the early stage of hepatocarcinogenesis.