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Vane, Sir John Robert

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Vane, Sir John Robert, 1927–2004, British pharmacologist, Ph.D. Oxford, 1953. With B. I. Samuelsson and Sune K. Bergström Bergström, Sune Karl (s
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, Vane was awarded the 1982 Nobel Prize in Physiology or Medicine. The trio won the prize for their identification and description of various compounds known as prostaglandins prostaglandin (prŏs'təglăn`dən)
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, which affect such functions as blood pressure and body temperature. Vane's work helped explain the effects on the body of aspirin aspirin, acetyl derivative of salicylic acid (see salicylate ) that is used to lower fever, relieve pain, reduce inflammation, and thin the blood. Common conditions treated with aspirin include headache, muscle and joint pain, and the inflammation caused by rheumatic
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, the world's most widely used drug and also contributed to the discovery and development of cox-1 and cox-2 inhibitors (see nonsteroidal anti-inflammatory drug nonsteroidal anti-inflammatory drug, a drug that suppresses inflammation in a manner similar to steroids, but without the side effects of steroids; commonly referred to by the acronym NSAID
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). He was knighted in 1984.


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