Virological Research

Virological Research

 

research for the detection of viruses, their identification, and the study of their bio-logical properties. For isolating viruses that come from man, animals, and plants, the material under investigation may be introduced into the organisms of experimental animals and plants that are sensitive to the viruses, or cell (tissue) cultures and organ cultures may be infected. The presence of the virus is proved by the characteristic affliction in the experimental animals (or plants); in tissue cultures it is proved by a lesion of the cells, the so-called cytopathologic action, which is recognized by microscopic or cytochemical investigation. The so-called plate method used in virologjcal research involves observing defects in the cellular layer caused by destruction or lesion of cells in foci of virus accumulation. Virions, which have a characteristic structure in different viruses, can be identified by electron microscopy. Further identification of viruses is based on the combined use of physical, chemical, and immunological methods. For ex-ample, viruses are distinguished by sensitivity to ether, which is related to the presence or absence of lipides in their shells. The type of nucleic acid of the virus (RNA or DNA) can be determined by chemical or cytochemical methods. Serological reactions with serum obtained by immunizing animals with the corresponding viruses are used to identify virus proteins. These reactions make it possible to recognize not only strains of viruses but also their varieties. Serological research methods based on the presence of antibodies in the blood permit the diagnosis of viral infections in man and higher animals and the study of the circulation of viruses among them. Special research methods are used to reveal latent (concealed) viruses in man, animals, plants, and bacteria.

REFERENCES

Shubladze, A. K., and S. la. Gaidamovich. Kratkii kurs prakticheskoi virusologii. Moscow, 1949.
Zhdanov, V. M., and S. la. Gaidamovich. Virusologiia. Moscow, 1966.

V. M. ZHDANOV

References in periodicals archive ?
Other child health conditions and issues to be studied in the centre include burns, childhood cancer, mental health, child development, rehabilitation and neurology, microbiological and virological research, and exercise and nutrition.
Under the heading "Warning: Be prepared for surprises", WHO praised progress in virological research that had increased capability to detect, understand and assess new viruses for pandemic risk, and to track their international spread.
ABL employs 100 people specialized in virological research.
Grant's broader virological research involving reexamination of data from several other UCSF studies for evidence of superinfection.
This approval is further validating the use of our next generation sequencing (NGS) downstream analysis software DeepChek[R]-HIV with several evaluations performed by renowned clinical and virological research centres and the positive results from several international scientific studies.
The virological research is mainly focussed on influenza viruses, which still represent a serious problem worldwide.