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adenine
(redirected from Vitamin B4)

   Also found in: Medical, Wikipedia 0.03 sec.
adenine (ăd`ənĭn, –nīn, –nēn), organic base of the purine purine, type of organic base found in the nucleotides and nucleic acids of plant and animal tissue. The German chemist Emil Fischer did much of the basic work on purines and introduced the term into the chemical literature in the early 20th cent.
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 family. Adenine combines with the sugar ribose ribose (rī`bōs), monosaccharide carbohydrate of universal distribution in living tissue, found in ribonucleic acid (RNA; see nucleic
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 to form adenosine, which in turn can be bonded with from one to three phosphoric acid units, yielding the three nucleotides adenosine monophosphate adenosine monophosphate (AMP) (ədĕn`əsēn mŏn'əfŏs`fāt)
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, adenosine diphosphate, and adenosine triphosphate adenosine triphosphate (ATP) (ədĕn`əsēn trī'fŏs`fāt)
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. These adenine derivatives perform important functions in cellular metabolism. Adenine is one of four nitrogenous bases utilized in the synthesis of nucleic acids nucleic acid, any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
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. A modified form of adenosine monophosphate is thought to be a secondary messenger in the propagation of many hormonal stimuli. Adenine is an integral part of the structure of many coenzymes biotin, is a member of the B complex; it was first isolated in 1935 from dried egg yolk, and its structure was established in 1942. Biotin is usually found attached to a lysine residue in certain enzymes, where it participates in reactions involving the transfer of carboxyl
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adenine

Organic compound of the purine family, often called a base, consisting of two rings, each containing both nitrogen and carbon atoms, and an amino group. It occurs free in tea and in combined form in nucleic acids, ATP, vitamin B12, and several coenzymes. In DNA its complementary base is thymine. It or its corresponding nucleoside or nucleotide may be prepared from nucleic acids by selective techniques of hydrolysis.


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