factor VIII

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factor VIII

[′fak·tər ′āt]
(biochemistry)
References in periodicals archive ?
It is a bleeding disorder in which deficiency of von Willebrand factor results in impaired primary hemostasis due to defective adhesion of platelets and destabilization of factor VIII protein.
Von Willebrand factor collagen binding (VWF:CB) activity was measured by an in-house ELISA assay using bovine Achilles tendon collagen type I for capturing (Sigma-Aldrich) and polyclonal rabbit anti-human VWF antibodies (DakoCytomation) for detecting.
Effects of desmopressin acetate on platelet aggregation, von Willebrand factor, and blood loss after cardiac surgery with extracorporeal circulation.
Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications.
Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis.
Thrombotic thrombocytopaenic purpura (TTP) is a rare multi - systemic disorder of small vessels that is associated with deficiency of the von Willebrand factor - cleaving protease ADAMTS,13 which promote platelet adhesion and aggregation, leading to multiple platelet thrombi in the microcirculation.
Von Willebrand Factor (VWF) is a polymeric plasma glycoprotein comprising multiple 250-kDa subunits that facilitates platelet adhesion to the vessel wall by linking platelet membrane receptors to the subendothelium and is the cornerstone of platelet--endothelial interaction.
ADAMTS-13 is a plasma metalloprotease that cleaves von Willebrand factor (vWF).
These tests include: E-selectin, asymmetric dimethyl arginine (ADMA), ICAM-1, VCAM-1, CD4OL, CRP, 11-1, TNF, IFN, MCP-1, von Willebrand factor, t-PA, PAI-1 and microalbumin.
Interquartile range increases in pollutant concentrations were consistently associated with statistically significant increases in fibrinogen, von Willebrand factor, heart rate, sCD62P, and SCD40L concentrations," they said.