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mutant |
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| More important, heterozygous and homozygous variant genotypes are consistently associated with higher CA than the wild-type genes. For example, disruption of a candidate gene should abolish the ability of the mutated pathogen to elicit disease in an animal model of infection, and reintroduction of the wild-type gene should reestablish virulence. Ideally, we'd like to put a mutant gene into a wild-type rat and see what happens to its blood pressure, or put a wild-type gene into a hypertensive rat and see if we can reduce blood pressure despite a high-salt diet," Herrera says. |
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