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see nephritisnephritis
, inflammation of the kidney. The earliest finding is within the renal capillaries (glomeruli); interstitial edema is typically followed by interstitial infiltration of lymphocytes, plasma cells, eosinophils, and a small number of polymorphonuclear leukocytes.
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an inflammation of the calyxes, pelvises, and parenchyma of the kidneys caused by the colon bacillus, staphylococcus, Pseudomonas aeruginosa, Proteus, and by other microorganisms. Primary, acute or chronic, and unilateral or bilateral forms of pyelonephritis are distinguished from secondary pyelonephritis, which is preceded by other diseases of the kidney and urinary tract. The morphologic changes associated with the disease take the form of clusters of cellular infiltrates. In chronic pyelonephritis, the kidney surface exhibits multiple cicatricial retractions. The cortical layer is thin and uneven.

Acute pyelonephritis often begins with fever, chills, and pain in the lumbar region. Urination is painful and frequent, and there may be headaches, nausea, and vomiting. Nitrogenous residues may increase in the blood in the early stages. The urine contains pus, red blood cells, albumin, and numerous bacteria, more than 100,000 per ml of urine. Treatment consists of antibacterial therapy with sulfanilamides, nitrofurans, and antibiotics. During the stage of fever, the intake of protein should be limited. Later the diet may be normal, with a copious intake of fluids, application of heat to the lumbar region, and antispasmodics.

The presence of chronic pyelonephritis is often revealed during urinalysis or the taking of blood pressure. The patient may complain of general weakness, headache, lack of appetite, pain in the lumbar region, and increased frequency of urination. The skin is pale and dry. The disease’s progress is bilateral. The urine’s specific gravity decreases and hypertension frequently develops, as does renal insufficiency. Diagnostic methods include urinalysis and examination of the renal functions, roentgenography, the use of radioisotopes, and occasionally biopsy of the kidneys. Treatment consists of prolonged antibacterial therapy with such drugs as nitrofurans, sulfanilamides, antibiotics, and NegGram. In the case of hypertension, hypotensive drugs are prescribed and the impaired urine flow is normalized. If such contraindications as renal insufficiency, obstruction of the urinary tract, and marked hypertension are absent, treatment in the Truskavets, Essentuki, Zheleznovodsk, or Sairme sanatoriums may be prescribed.


Pytel’, A. Ia., and S. D. Goligorskii. Pielonefrit. Moscow, 1961.
Ratner, N. A. Bolezni pochek i gipertoniia, 2nd ed. Moscow, 1971.



The disease process resulting from the effects of infections of the parenchyma and the pelvis of the kidney. Also known as interstitial nephritis.
References in periodicals archive ?
Xanthogranulomatous pyelonephritis in pediatric patients: Case report and review of literature.
Xanthogranulomatous pyelonephritis in a male child with renal vein thrombus extending into the inferior vena cava: A case report.
Xanthogranulomatous pyelonephritis in an Adolescen Urology 2010; 76 (6): 1472-1474.
Xanthogranulomatous pyelonephritis in adults: clinical and radiological findings in diffuse and focal forms .
Surgery done for infective etiology like pyonephrosis and xanthogranulomatous pyelonephritis, both open and laparoscopy had incidence of wound infection.
Development of fatal bilateral xanthogranulomatous pyelonephritis in a paraplegic patient: case report.
Xanthogranulomatous pyelonephritis in bilateral patients: A report of 25 cases.
2) Xanthogranulomatous pyelonephritis has been shown to be associated with transitional cell carcinoma of the renal pelvis and RCC.
Analysis of 39 cases of xanthogranulomatous pyelonephritis with emphasis on CT findings.
88%) of xanthogranulomatous pyelonephritis were seen, both of them were associated with renal calculi & found in female gender.
The prominent lymphoid background in the tumour presents a challenge for the pathologists in distinguishing LELC from inflammatory lesions such as xanthogranulomatous pyelonephritis.