Zaitsev Reaction

Zaitsev Reaction

 

a method of preparing tertiary alcohols from ketones using organozinc compounds:

where R′, R″, and R‴ are hydrocarbon radicals and X is a halogen. The Zaitsev reaction is a special case of a general method of synthesizing alcohols from compounds containing a carbonyl group developed by A. M. Butlerov and his stu-dents. Subsequently organomagnesium compounds came to be used in these syntheses, being more convenient to handle. A. M. Zaitsev discovered the reaction in 1885.

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