To optimize and determine the reaction conditions for synthesis 2-azetidinones using microwave technique, we attempted the reaction between 2-[1-(2-Chloro-4-iodo-phenylimino)ethyl]-4-iodo-naphthalen-1-ol and monochloroacetyl chloride in presence of [Et.sub.3]N using
2-methoxyethanol. The reaction went to completion within 4.3 min and corresponding product 2g was obtained in 90% yield.
[27.] Starek-Swiechowicz B., Szymczak W., Budziszewska B., Starek A.: Testicular effect of a mixture of
2-methoxyethanol and 2-ethoxyethanol in rats.
Ethanol (analytical reagent; Beijing Reagents Factory) and
2-Methoxyethanol (analytical reagent; Beijing Reagents Factory) were distilled before use.
Hydroxyproline was then assayed spectrophotometrically at 560 nm after reaction with 0.05 M of chloramine-T and 10% (w/v in
2-methoxyethanol) pdimethylaminobenzaldehyde.
Mehrotra, "Static dielectric constant and relaxation time for the binary mixture of water, ethanol, N,N-dimethylformamide, dimethylsulphoxide, and N,N-dimethylacetamide with
2-methoxyethanol," Bulletin of the Korean Chemical Society, vol.
The solvents used in the experiment were glacial acetic acid (C[H.sub.3]COOH) and
2-methoxyethanol ([C.sub.3][H.sub.8][O.sub.2]).
2-methoxyethanol and acetic acid were used as a solvent and chemical modifier, respectively.
Raikar, "Thermodynamic interactions in binary mixtures of
2-methoxyethanol with alkyl and aryl esters at 298.
Geoffroy, "Sol--gel processing of lead titanate in
2-methoxyethanol: investigations into the nature of the prehydrolyzed solutions," Journal of the American Ceramic Society, vol.
Recently, in order to develop a Dead Sea Minerals (DSM) based drug delivery system for topical therapy of skin diseases, polymeric nanoparticles based on Poly (maleic anhydride-alt-butyl vinyl ether) 5% grafted with monomethoxy poly(ethyleneglycol) 2000 MW (PEG) and 95% grafted with
2-methoxyethanol (VAM41-PEG) loaded with DSM were prepared by means of a combined mini-emulsion/solvent evaporation process.
Lead acetate trihydrate (Pb[([O.sub.2][CCH.sub.3]).sub.2]*3[H.sub.2]O, Pb[(OAc).sub.2]), and
2-methoxyethanol were purchased from Fisher Scientific.