As depicted in Figure 3 and Table 1,
5-FU significantly induced tissue erythema, mucosal ulceration affecting more than 25-50% of the mucosa, presence of abscesses and hemorrhage as detected by macroscopy (5[3-5]) and histopathology (3[2-3]) compared with the saline group (macroscopy: 0[0-0] and histopathology: 0[0-0], P < 0.05).
Effects of Quercus combined with
5-FU on viability of IEC-6 and Caco-2 cells
5-FU is an antimetabolite that suppresses cell division and causes cell cycle arrest.12 As a treatment for warts, topical
5-FU is primarily of historical interest, with most of the trials carried out in the 1970s and 1980s.
[IC.sub.50] ([micro]g/ml) Extract 281,16 n-hexane fraction 16,38 Ethyl acetate fraction 11,24 Ethanol fraction 483,32 Fucoxanthin 12,37
5-FU 11,84
The release profile of
5-FU from copoly(AMPS/AAm) nanohydrogels (i.e., S-2, S-6, S-7, S-8, and S-9) at two different pH levels; 1.2 and 7.4 was shown in Fig.
Although commonly seen with
5-FU infusion cardiotoxicity can occur with IV bolus also.
Furthermore, the information presented illustrates a cytotoxicity-effect reduction of the nanomaterials by
5-FU functionalization, evidencing the biocompatibility improvement of the nanobiomaterials.
ARPE-19 cells were treated with 5 mg/mL
5-Fu, 0.02 mg/mL MMC, 2.5 mg/mL BVZ, 5 mg/mL
5-Fu + 2.5 mg/mL BVZ, 0.02 mg/mL MMC + 2.5 mg/mL BVZ, or PBS as the control.
With this in consideration, the cytotoxicity of the 5-Fu-loaded 1a and the
5-Fu were studied against the HASM (human aortic smooth muscle) cells via the standard MTT method.
Treated both with the same doses and exposure time, the effect of licofelone on cell survival was clearly different than
5-FU (Figs.
And then, they were treated with
5-FU or Irinotecan at the varying concentrations for 6 days.