Dysregulation of
AKT has been implicated in a variety of rare overgrowth diseases and cancers; however, there are currently no approved inhibitors of
AKT.
There are some occasion which causes to cancer formation such as over expression of Akt1 and its activation level (phosphorylated
Akt) and site is link to development and progression of colon cancer (Roy et al.
After LIPUS stimulation, phosphorylation levels of PI3K and
AKT were markedly increased relative to the control group (P<0.01 or P< 0.001, Figure 3A).
LncRNA NEAT1 impacts cell proliferation and apoptosis of colorectal cancer via regulation of
Akt signaling.
Oral NaB group showed decreased genetic expression of AMPK (0.04 fold, p<0.001), mTOR (0.30 fold, p=0.04),
Akt (0.29 fold, p=0.67) and Sirt1 (0.83 fold, p=0.18).
We used the following antibodies: PI3K, p-Akt,
Akt, VEGF, and GAPDH (Cell Signaling Technology, MA).
They showed that
AKT comes in three distinct varieties residing in different kinds of brain cells and affecting brain health in very distinct ways.
Results showed that hypoxia-induced HSCs activation when
AKT phosphorylation was significantly enhanced (Figure 3(c)).
in [21] studied the mathematical model of PI3K/AKT signaling pathway in
AKT phosphorylation.
(Danvers, MA, USA) were as follows: GSK-3[beta] (BF0695), p-GSK-3[beta] (AF2016),
Akt (9272S), p-Akt (4060S), and [beta]-actin (8H10D10).
Additionally, it has been reported that ARRBs can initiate a second wave of signal transmission independent of G proteins through signaling pathways mediated by molecules such as protein kinase B (
AKT) and ERK; in these pathways, ARRBs act as multifunctional adaptors [4-7].