Direct comparison of 20-hour IV, 36-hour oral, and 72-hour oral
acetylcysteine for treatment of acute acetaminophen poisoning.
Thwin, "Outcomes after angiography with sodium bicarbonate and
acetylcysteine," The New England Journal of Medicine, 2017
Williams, "Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of
acetylcysteine," The Lancet, vol.
Medical-surgical nurses will recognize
acetylcysteine the reversal medication for acetaminophen overdose.
(30.) Aruoma OI, Halliwell B, Hoey BM, Butler J; The antioxidant action of N-
acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid.
Evaluation of nebulised
acetylcysteine and normal saline in the treatment of sputum retention following thoracotomy.
Patients with a life-threatening level of paracetamol in their blood are given
acetylcysteine by intravenous drip.
The study by Briguoriet al9 also emphasized the significance of
acetylcysteine dosage.
Those who presented later after their ingestion had more significant transaminase elevation despite treatment with the commonly recognized antidote,
acetylcysteine. Some late presenters had a course complicated by fulminant hepatic failure and acute renal failure, requiring up to two weeks' hospitalization.