Figure 2 shows an algorithm for the diagnosis of activated protein C resistance and the factor V Leiden mutation.
The assessment for activated protein C resistance is initiated by performance of a screening test using factor V-deficient plasma as a diluent for the patient plasma.
Cleavage of factor V at Arg 506 by activated protein C and the expression of anticoagulant activity of factor V.
Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.
Factor V gene mutation causing inherited resistance to activated protein C as a basis for venous thromboembolism.
Factor V Cambridge: a new mutation (Arg306 [right arrow] Thr) associated with resistance to activated protein C. Blood.
Factor V Arg 306 [right arrow] Gly mutation is not associated with activated protein C resistance and is rare in Taiwanese Chinese.