Numerous studies suggest that for the removal of somatic and germ cells in the ovaries of mammals and birds,
apoptosis is the mean molecular mechanism (Kumar and Joy, 2015; Chatterjee and Bhattacharjee, 2016).
Statins inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in the multistep mevalonate cascade for cholesterol synthesis.[17] Statins are widely used in the prevention of cardiovascular disease by lowering cholesterol.[17] Beyond their cholesterol reduction effect, statins have been shown to have pleiotropic effects.[15],[16],[17] Accumulating evidences indicated that the inhibition of the mevalonate pathway by statins induced ER stress and
apoptosis in cancerous and noncancerous cells.[17],[18],[19],[20] In this study, we explored the beneficial effect of simvastatin on ox-LDL-induced ER stress and
apoptosis in human vascular endothelial cells.
Positive Annexin V staining indicated early
apoptosis, and positive PI staining indicated binding to DNA which occurred when cell membranes disintegrated.
Persistence of HCV infection and consequent HCC is greatly attributed to the inhibition of
apoptosis and studies indicate that HCV proteins have pro and anti-apoptotic properties 5,6.
MBT induced cell
apoptosis and autophagy in HXORB44 cells
Keywords: Autoimmune disease, Dry eye, Impression cell,
Apoptosis.
Prostate
apoptosis response 4 (Par-4) is considered a proapoptotic factor.
have successfully identified the mechanism of mtDNA efflux during
apoptosis [14].
miRNAs regulate organism development, cellular differentiation and proliferation, and cell
apoptosis and death (Andreas et al., 2016; Pan, Toms, Shen, and Li, 2015; Xu, Linher-Melville, Yang, Wu, and Li, 2011).
Dr Stephen Tait, of the Cancer Research UK Beatson Institute, Institute of Cancer Sciences, said: "Our research found that triggering Caspase-Independent Cell Death (CICD), but not
apoptosis, often led to complete tumour regression.
It then activates downstream caspases (such as caspase-3) and leads to
apoptosis [23].