The MOD_PKA_2 motifs matched with amino acid residues CRVSGGE (279-285) that is part of a functional residue of secondary preference for PKA-type AGC kinase phosphorylation in cytosol, nucleus, and
cAMP-dependent protein kinase complex.
Ahn, "Activation of presynaptic
camp-dependent protein kinase is required for induction of cerebellar long-term potentiation," Journal of Neuroscience, vol.
Recently, genetic defects in
cAMP-dependent protein kinase type 1-[alpha] regulatory subunit (PRKAR1A) and cAMP-specific phosphodiesterase 4D (PDE4D) were identified in patients with acrodysostosis by candidate gene analysis (4) and exome sequencing (2,5) respectively.
Characterization of agonist stimulation of
cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies.
Goodman, "The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to
cAMP-dependent protein kinase A," The Journal of Biological Chemistry, vol.
It has been suggested that
cAMP-dependent protein kinase (PKA) signal pathway was involved in dopamine-mediated change of [Na.sup.+], [K.sup.+]-ATPase activity after short-term or long-term morphine treatment [47].
Adenylyl cyclase transforms ATP into cyclic AMP(cAMP), which in turn increases the activity level of
cAMP-dependent protein kinase A (PKA) [3, 4].
Clark, "Characterization of agonist stimulation of
cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies," Molecular Pharmacology, vol.