These proteins are important in neuronal differentiation, and regeneration proteins like ACTB, GSK3B,
CREB1, and CTNNB1 have physical interaction with coexpressed proteins [58].
UCA1, upregulated in CRC, inhibited miR-204-5p activity, thus promoting the upregulation of miRNA targets
CREB1, BCL2, and RAB22A (RAB22A, member RAS oncogene) and regulating cell proliferation and apoptosis [137].
CREB1 switches on another group of molecules linked to longevity called "sirtuins".
Doctor Giovambattista Pani, at the Catholic University of Sacred Heart, said: "Our hope is to find a way to activate
CREB1. For example, through new drugs, so to keep the brain young without a strict diet."
Learning-dependent gene expression of
CREB1 isoforms in the molluscan brain.
Genotyping identified all single nucleotide polymorphisms in a region that contained the
CREB1 gene.
In addition to its repressing function, our knowledge of MeCP2 has increased overtime, and it is now known that MeCP2 can interact with coactivator cyclic AMP-responsive element-binding protein 1 (
CREB1) to activate the expression of its target genes, alternate splicing sites via an interaction with YB1, a Y-box transcription factor, or regulate microRNA (miRNA) processing by interacting with DGCR8 to prevent the formation of the Drosha-DGCR8 complex [44].
However, with evaluation of one additional step, a plausible mechanism was revealed:
CREB1 can be activated by PCB 153 through the PXR (inhibition of an inhibitor) via documented direct binding interactions (Kodama et al.
In 2006, Antonescu et al (1) reported 3 of 3 cases of CCSLGT as showing translocations involving chromosomes 22 and 2 instead, resulting in fusions between EWSR1 and the
CREB1 gene.
AhR has been shown to regulate Ltbp-1 transcription by a mechanism involving recruitment of coactivators such as
CREB1 and corepressors such as HDAC2 to the Ltbp-1 promoter [44].
Among factors demonstrated to target this region,
CREB1 factor was described by the group of Peter van den Elsen to bind two cAMP response elements (CRE) at positions -1381 and -1371 (3' ends) from the ATG [76].