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calpain

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calpain

[′kal‚pān]
(cell and molecular biology)
A calcium-dependent cysteine protease in the cytoplasm that is central to most processes in cell biology (plasma membrane-associated signaling events; cell proliferation, differentiation, activation, and communication; and programmed cell death). Its overactivation has been observed in muscular dystrophy, Alzheimer's disease, AIDS, cataract formation, multiple sclerosis, and arthritis.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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References in periodicals archive
Assessment of Caspase-3, Calpain 1, and GABA-A Alpha 1 Activities
Evaluation of Behavior, Learning, Memory Along with Apoptosis, Neuronal Damage, and GABA-A Alpha-1 Receptor Level After Status Epilepticus in Immature and Mature Rats/Immatur ve Matur Sicanlarda Status Epileptikus Sonrasi Apoptoz, Noronal Hasar, GABA-A Alfa-1 Reseptor Miktari ile Davranis, Ogrenme ve Hafizanin Degerlendirilmesi
The optimum proteolytic activity of calpains was observed in the fresh meat of red deer - 0.085 um/h for one gram of protein (Fig.
Investigation on Autolytic Processes and Microstructural Changes in Red Deer Meat
Murphy, "Calpains, skeletal muscle function and exercise," Clinical and Experimental Pharmacology and Physiology, vol.
A Rare Case of Sunitinib-Induced Rhabdomyolysis in Renal Cell Carcinoma
Cells were serum-deprived for 24 hours and subsequently incubated for 30 min in the presence of BAPTA-AM (10 [micro]M) or the calpain inhibitors: calpastatin (1 [micro]M) or PD1506060 (100 [micro]M), followed by stimulation with either thrombin or PAR1-AP in DMEM/F12 medium for 5 minutes at room temperature.
Thrombin-Induced Calpain Activation Promotes Protease-Activated Receptor 1 Internalization
Lee, "Synthesis of chromone carboxamide derivatives with antioxidative and calpain inhibitory properties," European Journal of Medicinal Chemistry, vol.
Theoretical Study about the Effect of Halogen Substitution on the Reactivity of Antitumor 3-Formylchromones and Their Free Radicals
reported their novel findings that calcineurin, together with its upstream molecule, calpain 2, and downstream effector, NFAT-c3, plays a critical role in the development of AF in patients with vascular heart disease and diabetes.
Metabolic Mechanisms and Potential Therapies of Diabetic Cardiac Complications
Most muscular dystrophies (MDs) are caused by mutations in genes such as dystrophin, dysferlin, calpain, or LARGE like-glycosyltransferase [7-12].
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature
Calpain activities required in the myoblast fusion process and the proliferation of cell growth [15].
Growth characteristics of Indonesian thin tail Sheep (TTS) based on calpastatin (CAST) gene genotype variation
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