Activation of Nrf2 in keratinocytes causes
chloracne (MADISH)-like skin disease in mice.
Hanke, "Dioxin toxicity and
chloracne in the Ukraine," Journal of Drugs in Dermatology, vol.
In humans, exposure to dioxins has been linked to a variety of adverse effects, including
chloracne (Baccarelli et al.
Between June 1, 1966 and June 30, 2011 the applicant must have been diagnosed for one of the following prescribed medical conditions: CLC, soft tissue sarcoma, Hodgkin's disease,
chloracne, respiratory or prostate cancer, myeloma, transient peripheral neuropathy, porphyria cutanea tarda, type 2 diabetes or spinal bifida.
Additionally, exposure to PCDDs and PCDFs has been linked to myeloid leukemia,
chloracne, hemorrhaging, and carcinogenic effects, as well as promoting increased risk of cardiovascular and respiratory diseases (Bertazzi et al., 2001; Geyer et al., 2002; Pesatori et al., 1998).
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Chloracne or other acneform disease consistent with
chloracneAbout how the government long denied that exposure to Agent Orange could contribute to any ill-health except a case of
chloracne, a disfiguring skin condition.
Exposure to high levels causes the severe skin condition
chloracne. Ukraine's president Viktor Yushchenko had it in 2004.
They include
chloracne; Non-Hodgkin's lymphoma; soft tissue sarcoma (other than osteosarcoma, chondrosarcoma, Kaposi's sarcoma, or mesothelioma); Hodgkin's disease; porphyria cutanea tarda; multiple myeloma; respiratory cancers, including cancers of the lung, larynx, trachea, and bronchus; prostate cancer; acute and subacute transient peripheral neuropathy; Type 2 diabetes; and chronic lymphocytic leukemia.
Short-term exposure of humans to high levels of dioxins may result in skin lesions, such as
chloracne and patchy darkening of the skin, and altered liver function.
These include, for example, reproduction and development effects, depression of the immune system, severe skin conditions such as
chloracne, and cancers.