Mast cell
chymase and tryptase in abdominal aortic aneurysm formation.
Differential dagnosis of Kounis syndrome, Takotsubo cardiomyopathy, adrenaline-induced coronary vasospasm and the patient's data Feature Kounis syndrome Triggering Allergic reactions factor Mediators Mediators of mast cell degranulation (tryptase and
chymase), arachidonic acid products, histamine, platelet activating factor and several cytokines Pathogenesis Mast cell degranulation.
Van Heiningen et al., "Mast cell
chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE-/- mice," Cardiovascular Research, vol.
For immunocytochemical staining of tryptase and
chymase granules, the cells were collected from the matrix and fixed by using a fixation/permeabilization solution kit (BD Biosciences; CA).
In OLP, degranulation of mast cells releases proinflammatory mediators such as
chymase, TNF-[alpha], and tryptase.
Lindholt et al., "Critical role of mast cell
chymase in mouse abdominal aortic aneurysm formation," Circulation, vol.
(3) Like mast cells in the lungs or skin, they release histamine, leukotrienes, thromboxane, platelet activation factor (PAF), tryptase,
chymase, and renin once activated by allergic stimuli.
Beneficial effects of astragalus polysaccharides treatment on cardiac
chymase activities and cardiomyopathy in diabetic hamsters.
Histological characterization of mast cell
chymase in patients with pulmonary hypertension and chronic obstructive pulmonary disease.
Lee, A Combination of Receptor-Based Pharmacophore Modeling and QM Techniques for Identification of Human
Chymase Inhibitors, PLoS.
According to their granule contents, mast cells can be grouped as those containing tryptase but no
chymase and those containing tryptase,
chymase, and carboxypeptidase [13, 44, 45], each predominating in different locations [46].