estradiol

[‚es·trə′dī‚ȯl]

(biochemistry)

C₁₈H₂₄O₂ An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Estradiol

C₁₈H₂₄O₂, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]_D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

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References in periodicals archive

Zapoceto je lijecenje 17-beta estradiolom u obliku naljepka od 0,5 mg (Climara) zajedno s mikroniziranim progesteronom intravaginalno 2x100 mg (Utrogestan) kroz 3 mjeseca.

INDIVIDUALIZATION OF CUSTOM COMPOUNDED HORMONE THERAPY IN A PATIENT WITH CHEMOTHERAPY INDUCED PREMATURE OVARIAN INSUFFICIENCY AND IMPAIRED LIVER FUNCTION--CASE REPORT

(There is some question as to whether the fluctuating hormone levels from a pill may contribute to mood problems.) I would suggest that you might want to try another patch, since the Climara did not work for you, and see if that is better for you.

How can I reduce anxiety?

Climara Pro delivers a lower dose of estradiol (0.045 rag/day of estradiol and 0.015 rag/day of levonorgestrel) than CombiPatch, the first estrogen and progestin patch on the U.S.

FDA approves once-weekly hormone patch: vasomotor symptoms

Two randomized, controlled clinical trials showed that Climara Pro significantly reduced the frequency and severity of hot flashes as early as 1 week into therapy, and that 90% of women experienced an 80% reduction in hot flashes by week 12, according to Berlex Inc., a U.S.

FDA approves once-weekly patch for hot flashes: vasomotor symptoms

These include Prempro 0.3/1.5 and Prempro 0.45/1.5 with lower doses of estrogen and progestin, as well as Climara PRO, femhrt, Activella and Angeliq.

Progesterone

OSTEOPOROSIS DRUGS AT A GLANCE Oral bisphosphonates Actonel, Boniva, Fosamax Stops bone loss Intravenous Reclast Stops bone loss bisphosphonates Anabolic agent Forteo Builds bone Hormone Activella, Climara, therapies Estrace, Estraderm, Ortho-Est, Premarin, Prempro Selective estrogen Evista Slows bone loss receptor modulator DIETARY SOURCES OF CALCIUM * Plain nonfat yogurt, 8 ounces 452 mg Swiss cheese, 1 1/2 ounces 336 mg Provolone cheese, 1 1/2 ounces 321 mg Mozzarella cheese, 1 1/2 ounces 311 mg Skim milk, 1 cup 306 mg DIETARY SOURCES OF VITAMIN D ** Cod liver oil, 1 tablespoon 1,360 IU Salmon, 3 1/2 ounces cooked 345 IU Mackerel, 3 1/2 ounces cooked 320 IU Sardines, 1 3/4 ounces 250 IU Tuna, canned, in oil, 3 ounces 200 IU * IN MILLIGRAMS ** IN INTERNATIONAL UNITS

New weapons in the war on osteoporosis: a wide spectrum of drug therapies now give women with osteoporosis more options and better outcomes

estradiol and levonorgestrel patch (Climara Pro) Any of these products may be prescribed for menopausal symptoms, including vulvar or vaginal atrophy.

Estrogen