Procysbi (
cysteamine bitartrate) delayed-release capsules is a cystine-depleting agent indicated for the treatment of nephropathic cystinosis in adults and pediatric patients 1 year of age and older.
Unfortunately,
cysteamine could not be accessed in China despite repeated attempts.
Au-coated glass slide was then immersed in 10 mM
cysteamine solution for 2 hours and subsequently rinsed with deionized water to remove the residual
cysteamine.
TG2 Inhibitor,
Cysteamine, Attenuates ER Stress-Induced Social Interaction Deficits in Mice.
Cysteamine (AET) was purchased from Aladdin Reagent Company and used as received.
Granted orphan drug designation in November 2008, Cystadrops, which is an eye-drop solution for "the treatment of corneal cysteine crystal deposits in adults and children from two years of age with cystinosis", is the first eye-drop solution containing
cysteamine hydrochloride to be approved in the EU for this indication.
The aminothiol
cysteamine was shown to effectively reduce intracellular cystine concentrations both in vitro and in vivo (10) by forming a mixed disulfide with cysteine in the lysosome and allowing egress of the adduct through the PQLC2 transporter (11).
Therefore, supplementing maturation and culture media with antioxidants such as [beta]-mercaptoethanol, cysteine and
cysteamine can help to protect against defective embryo development (Abeydeera et al., 1998; de Matos and Furnus, 2000).
There are no reports describing the use of
cysteamine (Cystaran) in human pregnancy or lactation.