Phagocytic function of DC-SIGN modified DCs was enhanced, compared with the control group (phagocytosis rates: 74.0% [+ or -] 3.4% in DC-SIGN modified DCs; 64.7% [+ or -] 6.8% in control group, t = 3.104, P = 0.013).
The DCs function in promoting T cells proliferation did not significantly change among Ad-DC-SIGN/Af, AdNull/Af and control/Af groups.
In addition, Mannan/Af group secreted more IL-10 than control/Af group (Mannan/Af group: 30.17 [+ or -] 8.94 pg/ml; t = 4.146, P = 0.007), suggesting that Mannan and overexpression of DC-SIGN could promote secretion of IL-10 from Af-infected DCs [Figure 2]d.
Understanding how the DCS model complements understanding the needs of persons with disabilities may allow rehabilitation counselors to understand factors related to an individual's difficulty maintaining employment.
The DCS model provides some insight into various aspects of the environment and the potential experience of daily hassles.
Rehabilitation counselors should appraise the individual and the work environment in terms of the DCS model and provide career counseling to individuals based on this knowledge.