(2003) Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutation at these sites on
DNA end joining in a cell-free system.
Campbell et al., "The SOSS1 single-stranded DNA binding complex promotes
DNA end resection in concert with Exo1," The EMBO Journal, vol.
"It then performs a chemical reaction on the damaged
DNA end, reversing the damage and releasing it so that the broken DNA strand can be welded together with the rest of the double helix.
Actively dividing somatic cells do not effectively compensate the loss of telomeric sequences due to the
DNA end replication problem (Counter et al., 1992).
"During BIR, one broken
DNA end is paired with an identical DNA sequence on another chromosome and initiates an unusual type of replication, which proceeds as a migrating bubble and is associated with the accumulation of large amounts of single-strand DNA," she said.
Telomerase and
DNA end replication: no longer a lagging strand problem?
But he now highlights the condition through his Twitter feed @ColitisCop and often shares amusing stories about his previous struggles - not least when his
DNA ended up within a crime cordon after one episode when he was "caught short".
class="MsoNormalIn an effort to join the Pinye condemnation that was already full of logical gaps,
DNA ended up releasing the worst diss track of all time.