FVC = forced vital capacity; FEV1 = forced expiratory volume in 1 s; TLC = total lung capacity; RV = residual volume; DLco =
diffusing capacity of the lung for carbon monoxide; Sp[O.sub.2] = arterial oxygen saturation measured by pulse oximetry; A-aD[O.sub.2] = alveolar-arterial oxygen difference; ANA = antinuclear antibody; KL-6 = Krebs von den Lungen- 6; SP = surfactant protein; GAP = (gender (G), age (A), and two lung physiology variables (P) (FVC and DLco)).
Lack of improvement of lung
diffusing capacity following fluid withdrawal by ultrafiltration in chronic heart failure.
[SIII.sub.N2]: phase III slope of the nitrogen single-breath washout; FVC: forced vital capacity; [FEV.sub.1] forced expiratory volume in 1 s; DLco:
diffusing capacity for carbon monoxide; TLC: total lung capacity; RV: residual volume; MIP: maximal inspiratory pressure; MEP: maximal expiratory pressure; CV-VC: closing volume-vital capacity; 6MWD: 6min walking distance; Sp[O.sub.2]: peripheral oxygen saturation.
FVC: forced vital capacity; [FEV.sub.1]: forced expiratory volume in 1 second; [D.sub.L,CO]:
diffusing capacity for carbon monoxide; IL-6: interleukin 6; CRP: C-reactive protein; MMP-9: matrix metalloproteinase-9; N.A: not assessed.
(4) More advanced disease can present with pulmonary hypertension, cor pulmonale, pulmonary function tests (PFTs) indicative of mixed obstructive, restrictive process and low carbon monoxide
diffusing capacity (DLCO).4,5 A uniquely identifying clinical feature of this condition is the propensity of these patients for developing recurrent or bilateral pneumothoraces.
Pulmonary function tests may be normal in mild cases but generally there is restrictive ventilatory defect with reduced
diffusing capacity of the lung for carbon monoxide (DLCO).
(1) Most patients demonstrate impaired gas exchange, as evidenced by low oxygen-haemoglobin saturation at rest or on exercise; hypoxaemia on arterial blood gas sampling; or impaired
diffusing capacity (DLCO).
Diaz et al., "Single-breath
diffusing capacity of the lung for carbon monoxide: a predictor of Pa[O.sup.2], maximum work rate, and walking distance in patients with emphysema," Chest, vol.
In addition, higher levels of seven or more ACPAs were significantly more common in patients with evidence of restriction on a pulmonary function test and/or decreased results on a
diffusing capacity of the lungs for carbon monoxide test compared with those without ILD (39% vs.
Of all the tests in the pulmonary function laboratory, the single breath
diffusing capacity using carbon monoxide, DLCO, is the test most prone to inter and intra laboratory error and variation due to both faulty technologist technique and to general difficulties and complexities in measurement.
Pulmonary function was assessed with the postbronchodilator [FEV.sub.1] percent predicted, residual volume (RV)/total lung capacity (TLC) ratio, and the single-breath
diffusing capacity of the lung for carbon monoxide (DLCO) percent predicted [15].
(1975) Smoking and pulmonary
diffusing capacity. Scandinavian Journal of Respiratory Diseases 56, 165-83.